Metabolic Syndrome In Drug-na(?)ve Inpatients With Bipolar Disorder

Objective:To investigate the prevalence of Metabolic syndrome(Mets)in drug-na(?)ve inpatients with bipolar diorder(BD).Method: We examined 125 adult(aged 18–65 years)patients diagnosed with BD according to ICD-10 and 201 age-and gender-matched general people.The Mets was ascertained according to Chinese Diabetes Society(CDS)criteria.General demographic data,case characteristics,and metabolic index(body mass index(BMI),blood pressure,triglycerides,High-density lipoprotein cholesterol,fasting glucose,Total cholesterol,Low-density lipoprotein cholesterol)were recorded.Independent samples t-test and Pearson chi-square was applied for continuous variables,the chi-squared test or Fischer’s exact test was applied for categorical variables.Results:1.Between the patients,69(55.2%)patients were women and 56(44.2%)were men.The mean age was lower than the control group(36.75±10.91 vs 31.66±11.85,P < 0.01).2.BD patients showed higher prevalence of Mets compared to the population sample(9.6% vs 8.5%).After adjusting for age and gender confounders,the difference between the two groups was statistically significant(P<0.05).There was significant difference in the systolic blood pressure between the patients and population sample(127.66±16.21 vs 122.67±16.48,P<0.01).3.The prevalence of Mets is higher in female(14.5% vs 5.8%).Being BD,gender,age and BMI were independent risk factors for metabolic syndrome.4.There were no statistically significant differences in gender,age,metabolic components,or the prevalence of metabolic syndrome between patients in depressive(n=37)and manic-episodes(n=75).Conclusion:It indicated higher risk of comorbid with Mets in drug-na(?)ve BD patients.Being BD,gender,age and BM may be the mainrisk factors.