A Study On The Related Factors Of Metabolic Syndrome In Drug-naive Adolescents With Bipolar Disorder

Objectives:Understand the current status of metabolic syndrome related factors in drug-naive adolescents with bipolar disorder who have not been treated with psychiatric drugs,explore the factors that affect the occurrence of metabolic syndrome,and provide scientific basis for early prevention and treatment of metabolic syndrome.Methods:The sample of this study was taken from the outpatient and inpatient departments of Wuhan Mental Health Center,affiliated with Tongji Medical College,Huazhong University of Science and Technology.The experimental subjects were adolescents with bipolar disorder who did not use psychiatric drugs for treatment.A total of 55 patients were included in the analysis.Use the Beckmann Cours fully automated biochemical analyzer AU680 to measure patients’ blood lipids,uric acid and fasting blood sugar,and use measuring instruments to measure patients’ body mass index and waist circumference.The Chinese version of the Young’s Mania Scale,Hamilton Anxiety Scale,and Hamilton Depression Scale were used to evaluate the manic,anxiety,and depressive symptoms of patients.Compared with the normal healthy control group,the difference between the risk factors of metabolic syndrome: body mass index,waist circumference,blood lipids(triglycerides,total cholesterol,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol),uric acid and fasting blood glucose.At the same time,patients were divided into groups based on age,gender,total duration of the disease,duration of the current disease,and presence or absence of self injury behavior,and comparisons were made between different groups of patients;The above data were statistically analyzed using SPSS software.Results:Compared with the normal healthy population,the probability of developing metabolic syndrome in drug-naive adolescents with bipolar disorder is higher.The patient’s body mass index(t = 4.478,P<0.05),waist circumference(t = 9.583,P<0.05),triglycerides(t = 3.629,P<0.05),total cholesterol(t = 4.773,P<0.05),and uric acid(t = 4.519,P<0.05)are significantly higher than those in the normal healthy population.Male patients are more prone to abnormalities in uric acid(x~2 = 8.185,P<0.05)and low-density lipoprotein cholesterol(x~2 = 7.396,P<0.05)than female patients.The Hamilton Depression Scale scores of patients were positively correlated with triglyceride levels(r = 0.337,P<0.05);The score of the Young’s Mania Scale was negatively correlated with body mass index(r =-0.308,P<0.05),while the score of the Young’s Mania Scale was negatively correlated with uric acid value(r =-0.285,P<0.05);Hamilton’s anxiety score was negatively correlated with low-density lipoprotein cholesterol(r =-0.272,P<0.05),and there was a correlation between patients’ serum low-density lipoprotein cholesterol and the degree of anxiety symptoms(OR = 0.422,95% CI:-1.686,-0.42,P<0.05).Conclusions:Compared with healthy individuals of the same age,drug-naive adolescents with bipolar disorder are more likely to experience abnormalities in body mass index,waist circumference,triglycerides,total cholesterol,and uric acid,and are more susceptible to metabolic syndrome,and this susceptibility is not related to drug treatment.Male patients are more likely to experience uric acid abnormalities and low-density lipoprotein cholesterol abnormalities,while patients with a shorter overall course of disease are more likely to experience triglyceride abnormalities.Patients with manic symptoms have lower body mass index and uric acid levels,higher triglyceride levels in patients with depressive symptoms,lower low-density lipoprotein cholesterol levels in patients with anxiety symptoms,and lower low-density lipoprotein cholesterol levels as anxiety symptoms worsen.