The Analysis Of Risk Factors That Affect The Prognosis Of Patients With Cardiac Amyloidosis Diagnosed By Endomyocardial Biopsy

[Background]Cardiac Amyloidosis(CA)is a group of rare disease contributed to the deposition of insoluble fibrils in the extracellular of myocardium,resulting in dysfunction of heart by abnormality of architecture and toxicity of the myocardium.There are 8 types of amyloid fibril proteins that can deposit in the extracellular of myocardium,7 of which can influence organs systematically and 1 of which exclusively to heart.IObjective]To describe the characteristics and to identify the prognostic predictors of patients with cardiac amyloidosis.[Methods]This was a retrospective analysis,including the medical data of patients with Cardiac Amyloidosis diagnosed by EMB,who were admitted to the FuWai Hospital from January 2000 to February 2019.We carried out the follow-up visit through telephone.We used Kaplan-meier analysis to determine the risk factors of cardiac amyloidosis and Cox proportional hazard regression models to identify the independent predictor of outcomes.[Results]There are 25 patients with cardiac amyloidosis proven by EMB.There was no significant difference in survival between AL group and non-AL group.Cox proportional hazard modeling showed LDH≥242U/L(HR 5.774;95%CI,1.134-29.401;P=0.035)、positive urine protein(HR 5.006;95%CI 0.997,25.14;P=0.05)>significantly associated with the risk of mortality.And NT-proBNP≥8483 pg/ml is the independent factor for the prognosis of CA.[Conclusion]LDH≥242U/L、positive urine protein、right atrial enlargement and cTnI≥0.Ing/ml、NT-proBNP≥8483 pg/ml have prognostic value for patients with cardiac amyloidosis.