Analysis Of Clinicopathological Characteristics And Prognosis Risk Factors Of Triple-negative Breast Cancer

Objective:To investigate the clinicopathologic characteristics and the risk factors of Prognosis for triple-negative breast cancer(TNBC)by analyzing the clinical data and survival situation of TNBC patients.Methods:Retrospective analysis of clinical date of 92 TNBC patients admitted in our hospital from September 2010 to April 2012 and 100 non-TNBC patients admitted in our hospital in the same period Results:The difference in tumor size,histologic grade,age,menstruation was statistically significant(P<0.05)between TNBC group and non-TNBC group.There is no statistical differences in pathological pattern,lymphaden behavior,tumor site,family history(P>0.05)between TNBC group and non-TNBC group.The rates of size>5cm,age<35,grade 3 and non-menopause in 92 TNBC patients were higher than non-TNBC.Compared with the pathological results,the coincidence of ultrasound,mammography and combination of both method were 94.57%,84.78%,69.57%,respectively(P <0.001).Lymph node metastasis rate of TNBC increased with increment of tumor size(P<0.05).Follow-up results show that the rate of distant metastasis for TNBC was higher than non-TNBC(22.83% and 7.00%,respectively)and the DFS was lower than non-TNBC(59.78% and 71.00%,respectively),the difference was statistically significant(P < 0.05).According to survival curves of OS and DFS for TNBC and non-TNBC,the OS and DFS of TNBC was obviously lower than non-TNBC(5-year OS was 68.49% and 82.00%,5-year DFS was 59.78% and 71.00%,P<0.05).We also found that tumor size,lymph nodes metastasis,age,family history,positive expression of P53 and Ki67 were significantly related to death of TNBC.Logistic regression analysis further showed that larger tumor size,positive lymph nodes,positive expression of p53 and Ki67 weret independent prognostic factors of TNBC.Conclusion:Compared with the non-TNBC group,patients of TNBC group had younger age,larger tumor size,higher pathological level,the higher rate of distant relapse and metastasis and worse prognosis.Ultrasonography and mammography were the effective methods for auxiliary diagnosis of TNBC,and the combination of both methods can improve the detection rate of early TNBC.Larger tumor size,positive lymph nodes,positive expression of P53 and Ki67 were important independent prognostic factors of TNBC.TNBC patients who were prompted to poor clinical prognosis should be more aggressive treatment.