Clinical Observation On The Treatment Of Acute Radiation Esophagitis With Jizhi Bingshao Granule

Objective: to investigate the clinical efficacy and safety of radiation-induced esophagitis(jin deficient heat junction type)treated by bingshao granule of zhi striata.Methods: A completely randomized,positive parallel controlled clinical trial was used.In this study,64 patients with radiation esophagitis who met the inclusion criteria were randomly divided into experimental group and control group.The proportion of the two groups was 1:1.The experimental group was treated with Jizhi Bingshao granule(50ml each time,three times a day),and the control group was treated with western medicine suspension(gentamicin 240000 U + dexamethasone 10 mg lidocaine 30 ml + saline 500ml)(50ml each time,orally,three times a day),course of treatment: both groups began when the case had obvious radiation esophagitis,and took the corresponding drugs until the symptoms disappeared.The change process of injury grade,the change process of pain grade,the curative effect and change process of TCM syndrome of body heat deficit syndrome,and the standardized score of QLQ-C30 life scale before and after treatment were observed in the two groups to evaluate the curative effect.Hemogram,liver function and renal function were observed and analyzed.Results: TCM symptom evaluation: the two groups for eating astringent pain,chest and back burning pain,five heart heat can reduce the symptoms,there was no significant difference between the two groups(P < 0.05).For the treatment of dry mouth,dry pharynx,dry stool and dry skin,the treatment group was better than the control group(P < 0.05).Esophageal injury grade: there was no significant difference in the proportion of grade 1 and grade 2 between the two groups(P < 0.05).The proportion of grade 3 in the treatment group was significantly lower than that in the control group(P < 0.05).There was no grade 4 esophageal injury in both groups.From the generalized estimation equation,it can be seen that there is no difference in the degree of esophageal injury between the treatment group and the control group,and other related factors are included in the analysis model.It can be found that gender factors have an effect on esophageal injury(P < 0.05),indicating that the process of esophageal injury in patients of different genders is not consistent,which is worthy of further study.The days of medication in the treatment group were significantly less than those in the control group(P < 0.05).Pain grading: there was still no difference in pain grading between the two groups,P < 0.9517 / g / t < 0.05,indicating that there was no difference in the effect of esophageal pain classification between the treatment group and the control group.Quality of life questionnaire: the improvement of nausea and vomiting,constipation,role function,emotional function,fatigue,dyspnea and overall health status in the treatment group was better than that in the control group(P < 0.05).Conclusion: Compared with western medicine suspension,Ji Zhi Bingshao granule can also reduce the degree of esophageal injury and pain symptoms of patients,but the treatment group can significantly shorten the duration of symptoms,reduce the occurrence rate of grade 3 esophageal injury and improve the quality of life of patients.And the effect of dry mouth,dry pharynx,dry stool,dry skin and other symptoms was better than that of the control group.