Study On Therapeutic Function Of Compound White Peony Root Oral Liquids In Treating Clinical Acute Radiation-induced Esophagitis

Bjective: The clinical therapeutic function of compound white peony root oral liquids (cWPROL) were studied. The mechanism of therapeutic effect to clinical acute radiation-ind- uced esophagitis by cWPROL were discussed.Methods:119 case accorded with criterion of joining,14 case were excluded by criterion of exclusion. The 105 inpatients by radiotherapy are divided into two groups by method of stochastic analysis. There are 54 inpatients in group 1( chinese traditional medicinel group); there are 51 inpatients in group 2 (comparison group). There is similar in radiotherapy plus concurrent chemotherapy(RCT),gross radiative dose>58Gy,oesophagus length in irradiation area,classification of radiation-induced esophagitis between the two groups.All character of the two groups were basically similar and comparable. The chinese traditional medicinel group was giver the cWPROL(a dose daily, 10ml a time,ten times a day),slowlly swallow.After drinking cWPROL,the drink and food were prohibited.The comparison group was transfused with antibiotic and DMT 5mg(one times a day). The effect was observed after 5 days. The two groups were compared in clinical effect, concomitant symptom,transforma- tion of KPS score and avoirdupois.Results:1 Clinical study result show:In chinese traditional medicinel group , 13(24.07%)cases were basicly cured, 20(37.04%)cases were in effect, 21(38.89%)cases were of no effect,the overall effective rate were 61.11%. In comparison group, 8(15.69%)cases were basicly cured, 25(49.02%) were in effect, 18(35.29%)cases were of no effect,the overall effective rate were 64.71%.The clinical curative effect was no significantly different between two groups (P >0.05).2 Comparison of incidental symptom in curative effect:There were 37 cases with mouth dryness in chinese traditional medicinel group.After they were treated,27 cases were in effect, 10 cases were of no effect,the effective rate was 72.97%. There were 33 cases with mouth dryness in comparison group. After they were treated,8 cases were in effect, 25 cases were of no effect,the effective rate was 72.97%. The chinese traditional medicinel group was higher than the comparison group in the effective rate (P <0.01).There were 33 cases with constipation in chinese traditional medicinel group.After they were treated,27 cases were in effect, 6 cases were of no effect,the effective rate was 81.81%. There were 33 cases with constipation in comparison group. After they were treated,9 cases were in effect, 24 cases were of no effect,the effective rate was 27.27%. The chinese traditional medicinel group was higher than the comparison group in the effective rate (P <0.01).There was no significantly different between two groups with inability,sense of cautery and cough (P >0.05).3 Comparison of change in KPS score: 38 cases were in effect and 16 cases were of no effect in chinese traditional medicinel group; 32 cases were in effect and 19 cases were of no effect, There was no significantly different between two groups (P >0.05).4 Comparison of change in avoirdupois: 35 cases were in effect and 19 cases were of no effect in chinese traditional medicinel group; 23 cases were in effect and 28 cases were of no effect, The chinese traditional medicinel group was higher than the comparison group in the effective rate (P <0.05).Conclusion:1 cWPROL were effective medicament in treating II and III class acute radiation-induced esophagitis.2 cWPROL were same effect with western medicine,but unitary effect were better than western medicine.It accorded with result of basal experimentation.3 cWPROL have function of eliminating heat,detoxifcation and detumescence,accelerating blood and acesodyne,suppor- ting negative matter,growing flesh. The mechanism of therape- utic effect to clinical acute radiation-induced esophagitis by cWPROL were related with studying on restorative function for immunodeficiency, decreasing the hydroxyl radical (OH●) and NO, improving level of EGF,TGFβ1, restraining SP expression.