| PurposeBy observing the changes of TCM symptom scores before and after treatment in the treatment of patients with mild cognitive impairment of kidney deficiency,the changes of the Alzheim default knowledge scale,the simple mental state scale,and the scores of daily living self-care ability scale To evaluate its therapeutic efficacy and clinical safety for mild cognitive impairment of kidney deficiency,and to explore the traditional Chinese medicine basis and mechanism of Xingnao Yishou Recipe,so as to provide theoretical and clinical basis for the promotion and use of this side.Method1.General Information: Forty-six patients with kidney-deficiency MCI who met the requirements of this trial were enrolled in the Fuyang City Hospital from January 1,2017 to December 31,2017,and were randomly divided into controls.There were 21 patients in the group and 25 patients in the observation group.There were no significant differences in gender,age,education,occupation,duration of disease,and underlying diseases among the enrolled patients(p>0.05).All patients had pre-treatment TCM symptom scores,simple mental state scores,Alzheim default scale scores,daily routines.The scores of theself-care ability scale were statistically significant(p>0.05)and could be compared.2.Treatment: The control group was treated with YINGXINYE PIAN(Yangtze River pharmaceutical Group Co.,Ltd.),2 tablets at a time,3 times a day.The observation group was given orally to traditional Chinese medicine(the specific prescriptions are as follows: antler cream 30g(crushing),purple river car 10g(crushing),sputum 20 g,ginseng 10 g,asparagus 15 g,Ophiopogon 15 g,Rehmannia glutinosa 10 g,Angelica 15 g,Yizhiren(Salt)15g,Shichangpu 20 g,Suanzaoren(fried)20g,each addition of water to 400 ml,2 times orally,200 ml each time,respectively,after warm morning and evening,take the antler cream,purple before taking River car powder.The trials were performed for 24 weeks,and safety and efficacy evaluations were performed at weeks 0,4,12,and 24,and all patients were followed for half a year after the end of the treatment.During the trial,the patient pays attention to the combination of work and rest,the law of life,less spicy stimulation,cold and greasy food,moderate exercise.3.Observation indicators:(1)The efficacy evaluation mainly includes the changes of TCM syndrome scores,the ADAS-cog score,MMSE score,and the ADL-R score.(2)safety evaluation includes blood routine,urine routine,stool routine,liver and kidney function,blood sugar,blood lipids,and electrocardiogram.4.Statistical methods: The test results were processed using SPSS 25.0 statistical software.The data in the experimental study were expressed as(mean ± standard deviation)or(sx ±),which met the normal distribution and the homogeneity of the variance.The independent sample t test was used between the groups,and thepaired sample t test was used in the group.For comparison;non-normal distribution or non-conformity homogeneity data,the rank sum test was used between groups,and the paired sample rank sum test was used in the group for comparison.The count data in the experimental data were expressed using the frequency,and the 2 test was used for comparison.The rank data was tested by rank sum test.All statistical results were judged based on the obtained p value: p < 0.05 was statistically significant,and p > 0.05 was not statistically significant.Results1.There was no significant difference between the general data and the pre-treatment scores of all patients before treatment(p>0.05).2.TCM symptom scores: There was no significant change in TCM syndrome scores in the control group at the end of the experiment(p>0.05),and the TCM syndrome scores in the observation group were significantly lower than before(p<0.05),which was statistically significant compared with the control group(p< 0.05).3.Medical efficacy evaluation: According to the results of TCM syndrome before and after treatment,the patient’s medical efficacy was evaluated by nimodipine method,the total effective rate of the control group was 42.9%;the total effective rate of the observation group was 84.0%;compared with the control group,observation The group results were significant(p < 0.05).4.ADAS-cog score: The results showed that there was no significant difference between the control group and the control group at the end of the experiment(p>0.05).The score of the observation group decreased at the end of the experiment(p<0.05).Compared with the control group,the decrease was statistically significant.Academic significance(p<0.05).5.Cognitive function improvement: According to the results of ADAS-cog score,the scores of the scores before and after treatment were evaluated.The total effective rate of the control group was61.9%,and the total effective rate of the observation group was88.0%.Compared with the control group,the effective rate of the observation group was Significant clinical significance(p <0.05).6.MMSE score: The results showed that the scores of the control group did not change significantly before the test(p>0.05),and the scores of the observation group decreased compared with the previous ones(p<0.05).Compared with the control group,the decrease of the observed components was statistically significant(p<0.05).p < 0.05).7.ADL-R score: Results The scores of the two groups were higher than those before the test(p<0.05).There was no statistically significant difference between the two groups(p<0.05).>0.05).8.Safety indicators: Each patient underwent blood routine,urine routine,stool routine,liver and kidney function,blood glucose,blood lipids,and electrocardiogram before the test,the fourth week of the test,the 12 th week of the test,and the 24 th week of the test.At the end of the trial,a total of 5 cases with abnormal blood routine results were elevated white blood cells.All cases were asked to have upper respiratory tract infections,and the drug was treated symptomatically.After 2 weeks,the blood routines returned to normal.There was a case of acute gastrointestinal symptoms in patients with elevated white blood cells,and the symptoms improved after symptomatic treatment.Theresults were normal after one week.Two patients with fecal occult blood were considered to be caused by diet.After a week,the fecal occult blood returned to normal.Among the 3 patients with elevated blood glucose,1 of them had poor control of hypoglycemic regimen.The endocrinologists helped to adjust the blood glucose monitoring after adjusting the hypoglycemic regimen;2 patients had elevated blood glucose due to forgetting to take hypoglycemic drugs.Four patients with elevated triglycerides were considered to be related to the recent diet,and their attention was paid to adjusting the diet structure.The results of blood lipids review were decreased at the later visits.ConclusionXingnaoyishou Decoction has a significant effect on improving TCM symptoms,cognitive function and daily living ability in patients with kidney-deficiency MCI,and has high clinical safety,no significant adverse reactions,and is worthy of promotion. |
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