Clinical Study Of The Cardiac Involvement Of Children With Henoch Schonlein Purpura

OBJECTIVE Henoch-Sch?nlein purpura(HSP)belongs to leukocyte-breaking small vasculitis.It is a self-limiting disease with a prevalence of 2-14 years old.The basic lesion is diffuse small vasculitis,accompanied by Multiple systemic Ig A1 immune complexes deposited in the skin,joints,kidneys,gastrointestinal tract,etc.,can eventually cause damage to multiple organs.Most of the prognosis is generally acceptable,and a few cases of lesions can affect the heart,central nervous system,lungs and pleura,and some serious children can be life-threatening.In order to avoid the occurrence of severe cardiac complications and early diagnosis of HSP with heart damage,873 children with HSP admitted to our hospital from January 2010 to December 2016 were retrospectively analyzed.Methods To study the differences in clinical data between children with and without cardiac involvement,and to explore the risk factors for cardiac involvement in children with HSP,which can provide theoretical support for clinical diagnosis and treatment.METHODS A retrospective analysis was performed on 873 children with newly diagnosed HSP admitted to our hospital from January 2010 to December 2016.The clinical data collected were divided into two groups according to whether they were accompanied by cardiac damage: cardiac involvement group 221 There were 652 cases of non-cardiac involvement.Adrenal cortical hormone treatment was performed on all hospitalized children with HSP,supplemented with antihistamines,vitamin D,calcium tablets,vitamin C,dipyridamole or heparin sodium,and nutritional heart muscles with cardiac damage.Symptomatic treatment.Control and analysis of age,onset,clinical manifestations,electrocardiogram,myocardial enzymes,cardiac ultrasound,X-ray examination,C-reactive protein(CRP),group A β-hemolytic chain Laboratory tests for anti-bacterial infection(Antistreptolysin O,ASO),mycoplasma,coagulation,Helicobacter pylori,and complement.A telephone call back was performed after discharge from the hospital with a heart involvement.RESULTS 1.By comparing and analyzing the two groups of patients,compared with the non-cardiac affected group: male children(P<0.05),pre-existing respiratory infections(P<0.05),clinical manifestations of mixed HSP(P< 0.05),low complementemia(P<0.05),and high CRP(P<0.05).2.By multivariate logistic regression analysis of these parameters(the difference between the two groups of parameter control),it can be concluded that male,pathogenesis,mixed HSP and HSP were closely related to cardiac involvement(P<0.05).3.221 patients with HSP and cardiac involvement were followed up for more than half a year.Most of the symptoms of cardiac involvement were relieved soon after treatment and did not recur.CONCLUSION1.Children with HSP with cardiac involvement are more common in the clinic,and most of them have a good prognosis after treatment;2.Male children,pre-incidence and respiratory infections,and clinical manifestations of mixed allergic purpura may be more likely to bleed the heart.