Clinical Observation On The Therapeutic Efficacy Of TWP In 25 Cases Of Early Henoch-schnlein Purpura Nephritis In Children

Objective : To explore the impact of tripterygium wilfordii polyglycosidium(TWP) in children on microscopic hematuria and proteinuria of eraly Henoch-Schnlein purpura nephritis. Through 25 cases outcomes of patients with renal disease from Henoch–Schonlein purpura studies, this article will evaluate the effect of tripterygium wilfordii polyglycosidium for Henoch-Schnlein purpura nephritis.Method:We study the children diagnosed with Henoch-Schnlein purpura in our hospital from May in 2009 to November in 2009, we observed and recorded them the changes of urine sediment and quantitative examination of urinary microprotein, even after the diseases 4 weeks to 8 weeks. If microscopic hematuria was found, seventy percent of the red blood cells in urine had not normal-morphology, and proteinuria <50mg/(kg·d), we chose them as object. We thinked that they existed renal involvement. Henoch-Schonlein purpura is a systemic vasculitic disorder. Henoch-Schnlein purpura nephritis is renal involvement from Henoch-Schonlein purpura. In clinical, the patient can be diagnosed Henoch -Schnlein purpura nephritis if he was found hematuria and proteinuria after some time of Henoch-Schonlein purpura, in generally, in six months. 25 patients were choosed. They acceped symptomatic treatment and generally treatment. Neither they ate tripterygium wilfordii polyglycosidium 1mg/kg per day. We evaluated that whether their hematuria and proteinuria diminished after 3 months.Results:The urinary protein of two patients fastly enhanced in short time, could not be controlled. The urinary protein of three patients enhanced after four weeks of tripterygium wilfordii polyglycosidium. They had been treated with glucocorticosteroid. Four patients had not change after three months. Sixteen patients achieved stable remission. Conclusion:1.Tripterygium wilfordii polyglycosidium have the effert to eraly Henoch-Schnlein purpura nephritis. It can diminish hematuria and proteinuria.2.We need further study whether hematuria and proteinuria can achieved stable remission only to tripterygium wilfordii polyglycosidium.