Clinical Observation On The Treatment Of Premature Ovarian Inssufficiency,with Zishui Qinggan Yin Combined With Femoston

Objective:The purpose of this study was to study the clinical effect of Zishui Qinggan Yin combined with femoston in the treatment of premature ovarian insufficiency(POI).The clinical comprehensive curative effect,TCM symptom score,sex hormone level,antral follicle count,endometrial thickness,safety index,depression score,anxiety score and salivary cortisol related data were analyzed before and after treatment in the two groups.Objective to evaluate the clinical efficiency of integrated traditional Chinese and western medicine in the treatment of premature ovarian insufficiency,and to provide a reference for further study of the pathogenesis of physical and mental stress ovarian insufficiency.Method:From April 2017 to January 2018,a total of 40 complete cases were collected in Jiangsu Province Hospital on Integration Chinese and Western Medicine and met the crateria of this study.According to the random number table method,they were randomly divided into control group(n = 20)and treatment group(n = 20).The control group was treated with femoston,and the treatment group was treated with Zishui Qinggan Yin on the basis of the control group.After the course of treatment,the clinical curative effect indexes of the two groups before and after treatment were observed and compared,and their clinical effectiveness was analyzed.Results:1.Comparison of comprehensive curative effects:The effective rate was 90%in the treatment group and 85%in the control group,there was no significant difference between the two groups(P>0.05).The results showed that the comprehensive curative effect of the two methods was similar.2.Comparison of symptom points in traditional Chinese Medicine:The scores of TCM symptoms in the control group tended to decrease after treatment,but the difference was not statistically significant(P>0.05).The scores of TCM symptoms in the treatment group decreased significantly.The scores of TCM symptoms in the experimental group were significantly lower than those in the control group(P<0.01),and the scores of TCM symptoms in the experimental group were significantly lower than those in the control group(P<0.01).The results showed that the treatment group was especially effective in improving the symptoms of liver depressionand kidney deficiency in patients with POI.3.Comparison of serum sex hormone levels:The levels of serum follicle stimulating hormone(FSH)and luteinizing hormone(LH)in the two groups were significantly lower than those before treatment,and the levels of estradiol(E2)were significantly higher than those before treatment(P<0.01)).Comparison between the two groups after treatment,the level of serum FSH in the treatment group was lower than that in the control group,and there was no significant difference in the levels of serum LH and E2 between the treatment group and the control group(P>0.05).The results showed that both methods could significantly reduce serum FSH,LH and increase E2 in patients with POI,but the effect of traditional Chinese medicine combined with femoston on reducing FSH was better than that of femoston alone,and the effect of reducing LH and increasing E2 was the same.4.Comparison of B-Ultrasound related Indexes:After treatment,the number of antral follicles(AFC)was significantly increased(P<0.01)and the endometrium was significantly thickened(P<0.01).There was no significant change in the average area of ovary(P>0.05).After treatment,the number of AFC in the treatment group cwas significantly higher than that in the control group(P<0.01).There was no significant difference in endometrial thickness and average ovarian area between the treatment group and the control group(P>0.05).The results showed that both methods could increase the level of AFC in ovary,but the curative effect of traditional Chinese medicine combined with femoston was better than that of the control group.Both methods can thicken endometrium,but there is no significant difference in curative effect between the two methods.There was no significant effect on the change of ovarian volume in the two groups.5.Comparison of related Indexes of physical and Mental stress:The depression score and anxiety score of the two groups were decreased after treatment,the difference was statistically significant(P<0.05).There was no significant difference in salivary cortisol between the control group before and after treatment(P>0.05),but the salivary cortisol in the treatment group decreased significantly after treatment(P<0.01).After treatment,the anxiety score,depression score and salivary cortisol in the treatment group were lower than those in the control group,the difference was statistically significant(P<0.05).The results showed that both methods could improve the anxiety and depression of POI patients,but the effect of traditional Chinese medicine combined with femoston on improving anxiety or depression was more significant.In addition,traditional Chinese medicine combined with femoston can also reduce the level of salivary cortisol in patients with POI,while the use of femoston alone had no significant effect on the change of salivary cortisol level.Conclusion:Zishui Qinggan Yin combined with femoston is effective in the treatment of ovarian insufficiency of premature ovarian insufficiency.It was superior to the control group in increasing the number of antral follicles,improving the score of TCM symptoms,reducing the level of serum FSH,anxiety score,depression score and salivary cortisol.The results showed that the comprehensive clinical efficiency,the increase in the thickness of the uterus,the increase of serum E2,the decrease of LH level were similar.