| Objective:In recent years,the incidence of early threatened abortion has increased year by year.It has been found that the curative effect of combined traditional Chinese and western medicine is more remarkable than that of western medicine alone.Threatened abortion wich subchorionic haematoma(SCH)often occurs in the early trimester of pregnancy.As suggested by ultrasound,choriohaematoma is usually characterized by triangle,crescent,round,oval or irregular liquid dark areas.Early symptoms of premature abortion and subchorionic hematoma,if not controlled,will greatly increase the risk of termination,abortion.Early and effective treatment can improve pregnancy outcome and good clinical prognosis.However,the etiology and pathogenesis of threatened abortion combined with SCH are not clear,how to effectively treat the disease has become an urgent problem to be solved.The aim of this study was to observe the clinical efficacy of Jiaogai decoction combined with progesterone in the treatment of early threatened abortion with subchorionic hematoma,and to provide a new method and thought for the clinical treatment of this disease.Method:In this study,90 cases of patients who were diagnosed with early theratened abortion with SCH have hospitalized in Hubei Province,Maternal and Child Healthy hospital department of traditional Chinese medicine in March 2017~December2017.The 90 patients were randomly divided into group A1 and group A2,45 cases of patients each group.The group A1 was treated with modifided Jiao Ai Tang combined with progesterone of injection.The group A2 was treated with progesterone of injection,all groups were treated by 12 days.The clinical efficay,the rate of effecive tocolysis and pregnancy outcome follow-up were observed.The changes on TCM syndrome and human chorionic gonadotropin(β-HCG),estradiol(E2),progesterone(P)prothrombin time(PT),activated partial thromboplastin time(APTT),D dimer(DD)and SCH area were compared.at day 6 and day 12Results:(1)Finally 89 cases completed,one person lost the case caused the case to fall off,among 45 cases in group A1,44 cases in group A2.(2)As for clinical efficay,group A1 was better than A2,P<0.01,there was statistically significant difference between two groups.(3)The total effective tocolysis rates were93.33% in the group A1,77.27% in the group A2.,there was statistically significant difference between two groups(P<0.05).(4)The scores of TCM syndromes were reduced in the group A1 better than those in the A2 group,and the differences were statistically significant(P<0.01).(5)In the increase of bloodβ-HCG and E2 levels,the A1 group was significantly better than the A2 group,there was statistically significant difference(P<0.05),but there was no significant difference between the two groups in the increase of blood(P>0.05).(6)Two groups both can prolong PT,shorten APTT,reduce DD,and the effect of A1 group is better than A2 group,especially in reducing DD.There is no significant change in group A2 after treatment for D6 days,and it is reduced in treatment D12 days.There was significant difference between the two groups(P<0.01).(7)In the reduction of SCH area,the A2 group was significantly slower than the A1 group,and the reduction rate of A1 group was significantly better than that of A2 group,the difference was statistically significant(P<0.05).(8)No adverse reactions were observed in the A1 group and the A2 group during the treatment.Conclusion: Modifided Jiao Ai Tang combined with progesterone is effective in treating early threatened abortion with SCH.It can significantly reduce the scores of TCM syndromes,reduce the area of liquid dark area,increase the level of human chorionic gonadotropin,estradiol and progesterone,improve the effective tocolysis rates,rehuce abortion rate.Inaddition,the Chinese medicine has no poisonous effects,is worthy futher study. |
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