Clinical Study Of Zishen Huoxue Decoction In The Treatment Of IgA Nephropathy With Liver-Kidney Yin Deficiency And Blood Stasis

Observation To observe the therapeutic effect of Zishen Huoxue Decoction on Ig A nephropathy of liver and kidney yin deficiency combined with blood stasis,and the influence of this prescription on relevant laboratory indicators.Then to evaluate objectively and scientifically the clinical efficacy and safety of Zishen Huoxue Decoction in treating Ig A nephropathy of liver and kidney yin deficiency combined with blood stasis.Method Using single blind method,60 patients were randomly divided into control group and experimental group according to the principle of simultaneous control trial,and the ratio of control group and experimental group was 1:1.The control group was treated with irbesartan tablets and dipyridamole tablets.On this basis,the experimental group was treated with Zishen Huoxue Decoction,the experience prescription of the tutor.The two groups were treated continuously for 12 weeks.After the treatment,the total effective rate,the curative effect of TCM syndromes and laboratory indicators of the two groups were analyzed by statistical methods,and the final results were obtained.Result 1.Basic Situation: Before treatment,the two groups of cases were analyzed by statistics on gender,age,course of disease,TCM symptoms and related laboratory indicators.The results were P > 0.05,with no statistical significance and comparability.2.Total effective rate: after treatment,the total effective rate of the experimental group was 93.33%,while that of the control group was 66.67%.After statistical comparison,P = 0.016 < 0.05,with statistical significance.3.TCM syndromes: After treatment,the clinical symptoms of TCM in the experimental group were significantly improved,the effective rate was 86.67%,while that in the control group was 66.67%.After statistical comparison,P = 0.015 < 0.05,with statistical significance.4.Laboratory indicators: After treatment,proteinuria,24-hour urinary protein quantification and urinary erythrocyte count were significantly reduced in the experimental group,and plasma viscosity,triglyceride and total cholesterol were reduced.Statistical analysis showed that the therapeutic effect of the experimental group was better than that of the control group(P < 0.05),with statistical significance.The experimental group and the control group can reduce plasma fibrinogen after treatment.Compared with the two groups,the experimental group is not superior to the control group,and there is no statistical significance(P > 0.05).5.Safety indicators: Before and after treatment,the safety indicators(vital signs,blood routine,liver and kidney function,electrolyte)of the two groups were statistically analyzed.The results showed that there was no significant difference between the two groups before and after treatment(P > 0.05).Conclusion Compared with the control group,the experimental group could not only improve the clinical symptoms of traditional Chinese medicine,but also significantly reduce proteinuria,24-hour urinary protein quantification and urinary red blood cell count,as well as plasma viscosity,triglyceride and total cholesterol.Statistical analysis showed that the efficacy of the experimental group was significantly better than that of the control group.