Analysis Of The Outcomes Of Ketosis-prone And Non Ketosis-prone Newly Diagnosed Early-onset Type 2 Diabetes Mellitus Patients With Obesity Treated By Liraglutide After 1 Year

Objectives:To analyse the outcomes of ketosis-prone and non ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity treated by Liraglutide after 1 year.Methods:The ketosis-prone and non ketosis-prone newly diagnosed early-onset type 2diabetes mellitus patients with obesity whose FPG > 11.1mmol/L and(or)Hb A1 C ≥9.0% were selected as the subjects who were from the inpatient department of the Second Affiliated Hospital of Da Lian Medical University in September 2014-2016.On the second day of being in hospital,their Hb A1C、FPG、FINS、FC-P、1h-PG、1h-PCP、1h-PINS、2h-PG、2h-PCP、2h-PINS、IGD-Ab、ICA、IAA、TC、TG、LDL-C、HDL-C、Apo-A1、Apo-B、UA、ALT、AST and urine ketosis were selected.After selecting these above,they were all intensively treated by insulin pump for one week.After treatment,there were 88 cases whose FPG reached target range and Urine ketone were negative,including 42 ketosis-prone newly diagnosed early-onset type 2diabetes mellitus patients with obesity and 46 non ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity.They were all treated by 1.2mg Liraglutide injected every day when they were out of patient.Every 3 months to 6months and one year,we selected these indexes as above and calculated BMI.After following up one year,these indexes were monitored again.Analyse the outcomes of ketosis-prone and non ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity treated by Liraglutide after 1 year.Results:1.At the baseline,the Hb A1 C 、 HOMA-IR 、 TG of ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity were higher than non ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients(P<0.05),FCP and 2h-PCP were lower than non ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients,the difference was statistically significant(P<0.05).2.After one year of treatment,the FPG、Hb A1C、2h-PG、HOMA-IR、BMI、TG、TC of the ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity were lower than the baseline,the difference was statistically significant(P<0.05).FCP was higher than the baseline,the difference was statistically significant(P<0.05).3.After one year of treatment,the FPG、Hb A1C、2h-PG、HOMA-IR、BMI、TG、TC of the non ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity were lower than the baseline(P<0.05),FCP was higher than the baseline,the difference was not statistically significant(P<0.05).4.After one year of treatment,the ?FPG、?2h-PG、?HOMA-IR、?BMI of the ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity were higher than the non ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients,the difference was statistically significant(P<0.05).But the difference of ?FCP、?TG and ?TC were not statistically significant(P>0.05).5.The ?BMI and ?HOMA-IR were the effecting factors of the outcomes about the ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity and non ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity.Conclusions:1.Comparing of the non ketosis-prone newly diagnosed early-onset type 2diabetes mellitus patients with obesity,the islet functions of ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity were worse,the plasma glucose and serum lipid of which were higher,the ristance of insulin was more significant.2.After one year of treatment,the islet function of the ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity got better than before,the plasma glucose and insulin resistance and serum lipid were all improved of the non ketosis-prone and ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity,but the degree of improvement of non ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients was more significant.3.The?BMI and ?HOMA-IR were the effecting factors of the outcomes about the ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity and non ketosis-prone newly diagnosed early-onset type 2 diabetes mellitus patients with obesity.