Clinical Characteristics And Classification Of Young And Middle-aged Patients With Ketosis-prone Diabetes

Objective:To investigate the clinical characteristics and classification of young and middle-aged patients with ketosis-prone diabetes.Methods:71cases of young and middle-aged patients with Ketosis-prone diabetes, according to the antibody can be divided into positive and negative groups, antibody negative groups according to body mass index (BMI)divided into obesity group and non obesity group, according to the function of B cells retained or not divided into B+and B-group, and compare different groups with the sex ratio (male/female), age, family history, hypertension history, body mass index (BMI), glycosylated hemoglobin (HBAlC), fasting C peptide (FCP), blood lipids and so on, then followed for at least six months, compare with blood sugar level, islet function and clinical alleviate, insulin dependence. And50cases of the common type2diabetes mellitus as taken as control group. Results:1、Young and middle-aged patients with Ketosis-prone diabetes with an average age of41years old,63.4%are overweight or obese patients, male more than female obviously, male/female was1.9:1,more were lipid disorders,most could be discontinued insulin;2、Compared with type2diabetes, young and middle-aged patients with Ketosis-prone diabetes were many similar clinical features and pathophysiological characteristics;3、Ketosis antibody negative than positive group, family history, hypertension history, body mass index, islet function has significant difference; after Six months islet function was significantly better than the positive group, and significantly higher proportion of the Clinical remission and discontinued insulin;4、In Antibody negative, obese compared with not obese group, body mass index, hypertension history, family history has significant differences; after Six months islet function significantly better than not obesity group, the blood sugar level drops more apparent, higher clinical level and discontinued insulin;5、In antibody negative,B+compared with B-group, body mass index, triglyceride levels, fasting C peptide levels had significant difference; after six months islet function significantly better than group B-Better blood glucose control, higher clinical remission and discontinued insulin.Conclusions:Young and middle-aged patients with Ketosis-prone diabetes were mostly male obese patients, Combined with blood lipid disorder,, most after short-term insulin treatment could convert oral drugs, or even clinical remission, clinical features and prognosis similar with type2diabetes, most of them can be classified as type2diabetes.