Functions Of Thymic Stromal Lymphopoietin In Allergic Diseases Surveillance And Its Preliminary Of Study On Non-small Cell Lung Cancer

Thymic stromal lymphopoietin(TSLP),which is mainly secreted by the epithelial cells,stromal cells and mast cells,is a IL-7 like cytokine.It palys an important role in activating dendrtic cells and inducing the differentiation and mature of lymphocytes.At the same time,TSLP is essential for the initiation and development of Th2-mediated allergic inflammation by acting on myeloid and lymphoid populations to coordinate innate and adaptive immunity.Sports fatigue can directly affect the competitive athletic ability of athletes.After a long-term intensive training with fatigue,athletes always gain Th1/Th2 imbalance,which results in decline of anti-infection ability and in susceptibility to colds,upper respiratory tract infection and skin diseases.In this study,we collected several cyclists’ serum by one year continuous tracking and detected the expression of cytokines in serum to investigated the role for TSLP in cyclist allergic inflammation monitoring.We found the correlation of serum interleukin 9 and TSLP concentration in atopic cyclist.By calculating the value of IFNγ/TSLP as well as IFNγ/IL-9 representing Th1/Th2 and Th1/Th9 respectively,we demonstrated TSLP and IL-9 were an effective marker for measure the sports immune imbalance.As we know,inflammation palys an important role in different stages of cancer.Thus,TSLP holds promise as a novel therapeutic target for asthma and other allergic diseases with the depening of the reseach.In china,lung cancer has become the leading cause of cancer-associated cancer,among which non-small-cell lung cancer(NSCLS)accounts for 80%.But nearly two-thirds of patiens with NSCLC were already late when diagnosed and the prognosis of NSCLC was still poor though the effective rate of chemotherapy had a certain improvement.By cultivating human NSCLC cell lines,we detected the expression of TSLP in these cell lines and investigated the role for TSLP in the pathogenesis of NSCLC.According to the data,we preliminarily clear tumor cells could not release TSLP however could release TNFα,which may induces the release of TSLP by cancer associated fibroblasts,and finaly have a influence on the development of cancer.