Correlation Of Frank’s Sign And Adropin

Objective: To explore the correlation between Frank’s sign and Adropin,and try to elucidate the possible mechanism of Frank’s sign and the theoretical basis of Frank’s sign related to coronary atherosclerotic disease.Provides possible new ways for primary prevention of CAD and a theoretical basis for secondary prevention.Methods:(1)Research object: A cross-sectional study method was adopted,and collection was conducted between November 2015 and October 2016 in the Department of Cardiology of the People’s Hospital of Shaanxi Province,aged between 18 and 70 years old,with no relation to each other.A total of 133 inpatients underwent coronary angiography(CAG).(2)Study group: a.According to CAG results,74 cases were divided into CAD group,including 48 males and 26 females,with an average age of 63.01±5.53 years;59 non-CAD groups,34 males and 25 females,mean age was 60.08±6.59 years old;b.According to Frank’s sign or not divided into Frank’s sign positive group of 56 patients,37 males and 19 females,mean age was 65.09±1.20 years old,77 patients with Frank’s sign negative group,45 males,32 females and their average age was 55.45±1.70 years old.c.According to whether there were CAD and combined with Frank’s sign or not divided into: Frank’s sign positive CAD group 57 cases,inclunding 36 males and 21 females,mean age 66.16±5.53years;Frank’s negative CAD group 19 cases,11 males,8 females,and their average age was60.53±4.25 year;in the Frank’s negative non-CAD group,there are 57 cases,35 males and22 females,with an average age of 50.10±6.65 years.(3)Data collection: Collected clinical baseline data of all subjects included in the study,including age,gender,past disease and family history,Hb A1 c,and six lipids(mainly including total triglycerides,total cholesterol,and high-density lipoprotein cholesterol,Low-density lipoprotein cholesterol,apolipoprotein A1 and apolipoprotein B1),renal function(mainly including blood urea nitrogen,serum creatinine,blood uric acid,blood cystatin C,retinol protein)and other indicators.The results of coronary angiography(CAG)were recorded in this population.(4)Recruit the 5 ml of fasting blood from the morning of the next day after admission to the hospital and centrifuge at 3500r/min for 15 minutes.Take the supernatant and store it in a refrigerator at-80°C for analysis.Adropin levels were determined by ELISA.(5)All data were analyzed statistically using SPSS 19.0 statistical software.Measured datawere expressed as mean±standard deviation(X(-)±s).The comparison between the two groups was performed using the t-test;counting data was expressed as a percentage.χ2test was used for comparison between the two groups.Logistic multivariate regression analysis was used to investigate the independent factors related to the Frank’s sign.Results:(1)The serum total cholesterol in the CAD group and the non-CAD group were:4.01±1.17(mmol/L)vs 3.15±1.16(mmol/L)(P<0.05);the low-density lipoprotein cholesterol was: 2.19±0.89(mmol/L)vs 1.90±0.47(mmol/L),(P<0.05);High-density lipoprotein cholesterol was: 1.01±0.23(mmol/L)vs 1.14±0.28(mmol/L)(P<0.05);serum Adropin concentrations were: 215.38±1.50(mmol/L)vs 358.58±1.91(mmol/L),(P<0.05).(2)The average ages of the Frank’s syndrome positive group and the Frank’s syndrome group negative were 65.09±1.20(years old)vs.55.45±1.70(years)(p<0.05);Serum Adropin concentrations in the Frank’s syndrome group and the Frank’s syndrome group were negative.The levels were: 168.85±1.01(pg/ml)vs 349.00±1.89(pg/ml).(P<0.05).(3)In this study,Frank’s sign positive group was diagnosed as CAD.The serum Adropin concentrations in the Frank’s syndrome positive CAD group,the Frank’s syndrome negative CAD group,and the Frank’s syndrome negative non-CAD group were: 177.21±1.16(pg/ml)vs 316.24±1.75(pg/ml)vs 392.04±1.92(pg/ml)(P<0.05).(4)Logistic single-factor regression analysis showed that Frank’s sign was an independent risk factor for CAD when CAD was the dependent variable(p<0.01).When Frank’s sign was the dependent variable,low serum Adropin concentration was a susceptibility factor for Frank’s sign(p<0.01).Conclusions:(1)The level of Adropin levels lowering are associated with earlobe crease sign.(2)The Frank’s sign can be used as an early screening indicator of CAD.