Clinical Observation Of Yishen Tongluo Prescription Combined With Glucocorticoids In Treating Iga Nephropathy

Objectives:To treat patients with qi stagnation and blood stasis due to Ig A(A immunoglobulin,Ig A)nephropathy by using Yishen Tongluo Prescription combined with glucocorticoid(GC),and to record and analyze the hematuria of the experimental group and the control group before and after treatment by statistical analysis.Changes in proteinuria,clinical symptoms,TCM symptom scores,etc.To understand the clinical efficacy and safety evaluation of Yishen Tongluo Fang for patients with qi stagnation and blood stasis Ig A nephropathy,and to provide a theoretical basis and clinical thinking for the treatment of Ig A nephropathy with integrated traditional Chinese and western medicine.Methods:Patients with clinical pathological type of Ig A nephropathy were collected for clinical renal biopsy.60 patients who met the inclusion criteria were divided into experimental group and control group according to the random number table,30 cases in each group.The control group used only sufficient amount of GC,and the test group used Yishen Tongluo Prescription combined with sufficient amount of GC.Before the trial began,statistical analysis was performed on the age,course of disease,gender,hematuria,and proteinuria of the two groups of patients.The balance of the two groups of data was comparable.The total duration of medication was 6 months.Observe and record the efficacy indicators and safety indicators before and after treatment,and perform statistical analysis.Research result:1.A total of 60 subjects in the test group and the control group completed the test on schedule and no significant adverse events or accidents occurred.2.After 6 months of treatment,the urinary sediment red blood cell count and 24-hour urinary protein(24UTP)decreased in both groups(P<0.01),and the decrease was more significant in the test group than in the control group.The results were statistically significant(P<0.05).3.After 6 months of treatment,urinary occult blood test(BLD)and urinary protein(Protein,PRO)decreased in both groups(P<0.05),and the drop in the test group was more significant.The results were statistically significant.Difference(P<0.05).4.After 6 months of treatment,the scores of the two groups of TCM syndromes were lower than before(P<0.05),and the experimental group was more obvious.The results were statistically significant(P<0.01).5.After treatment for 6 months,the total effective rate of TCM syndromes in the experimental group was 93.33%;the total effective rate of TCM syndromes in the control group was 73.33%.The TCM efficacy of the TCM group was more significant than that of the control group(P< 0.05).6.After 6 months of medication,the total effective rate was 96.66% in the experimental group,and 80% in the control group.The clinical efficacy of the experimental group was more obvious.The results were statistically significant(P<0.05)..Conclusions:1.The efficacy of Yishentongluo combined with glucocorticoids in the treatment of Ig A nephropathy patients with qi stagnation and blood stasis is significantly better than that of glucocorticoid alone.2.Yishen Tongluo Fang has improved urine protein,urine occult blood and urinary sediment red blood cells in patients with Ig A nephropathy,and some of the drugs have anti-inflammatory,anti-inflammatory,anti-coagulant,anti-osteoporosis and other effects,which can shorten the disease.Therapeutic treatment,and can reduce the side effects of glucocorticoids.3.Ig A nephropathy long course of treatment,patients prone to liver qi stagnation,emotional problems,Yishen Tongluo Fang Bupleurum,Campanulaceae,Achyranthes,Citrus aurantium are Qishen drugs,can adjust the patient’s Mental state to recover from illness.