Analysis Of Vaginal Microecological Status Of Women With HR-HPV Infection More Than 6 Months

Objectives:By analyzing the vaginal microecological status of women with HR-HPV infection over 6 mouths and healthy women who visit the NO.2 hospital of Jilin University at the same period,to find the risk factors of HR-HPV persistent infection.Detect and regulate the possible imbalance of vaginal microecology in women with HR-HPV infection more than 6 months,in order to prevent the further development of the cervical disease.Methods:Randomly selected women from the Department of Gynecology at our Hospital of Jilin University between December 2016 and December 2017 as research subjects.Study group: 320 women,who’s HR-HPV test result was find positive first time 6 to 8 months ago,and the HR-HPV test results were still positive this time.Control group: 125 women,who had no past history of HP-HPV infection,and the HR-HPV test results were still negative this time.The vaginal microecological test used the bPR-2014 A Vaginal Microecology Evaluation System of Shuoshi limited liability company.The contents of the test were divided into vaginal micro-ecological morphology tests and functional tests.The former included vaginal flora concentration,bacterial diversity,dominant bacteria,white blood cell count/high magnification field of view.The latter included Nugent scores,PH values,and hydrogen peroxide,salivary anhydrase,leukocyte esterase,β-glucuronidase,acetylglucosaminidase.The HR-HPV test used the hybrid capture 2 generation(HC-II)HR-HPV gene hybridization signal amplification system of United States Digene Group.The two sets of test results were summarized and statistically processed using IBM SPSS 24.0 software.Measurement data were expressed as mean±standard deviation(x±s).The t-test was used to compare the set mean of measurement data;χ2 test was used to compare the set of counting deta.P﹤0.05 was considered statistically significant,and P﹤0.01 was considered more statistically significant.Results:1.The results of vaginal microecology assessment between the study group and the control group: HR-HPV infection in women over 6 months compared with healthy people,intravaginal PH value ≥ 4.6,lack of hydrogen peroxide,positive sialicase,positive leukocyte esterase The discovery rate has a rising trend,and the difference is statistically significant(P﹤0.05).Over 6 months of HR-HPV infection in women with abnormal vaginal flora density,abnormal bacterial flora,abnormal bacteria,vaginal discharge leukocytes ﹥10/high magnification field,β-glucuronidase positive,and acetyl-glucuronoside The positive rate of enzyme positive was higher than that of healthy people,but the difference was not statistically significant(P﹤0.05).2.The combined results of vaginal microecology of the study group and the control group showed that the detection rate of normal vaginal microecology in women with HR-HPV infection more than 6 months was lower than that in healthy women,and the difference was more statistically significant(P﹤0.01).The detection rate of BV in women with HR-HPV infection more than 6 months was higher than that in healthy women,and the difference was statistically significant(P﹤0.05).The detection rates of TV,VVC,vaginal mixed infection,abnormal flora,and microecological dysfunction in women with HR-HPV infection more than 6 months were higher than those in healthy women,but the difference was not statistically significant(P﹤0.05).Conclusion:1.The incidence of vaginal PH value ≥ 4.6,hydrogen peroxide deficiency,positive sialicidase,leukocyte esterase positive,and bacterial vaginosis was higher in women with HR-HPV infection more than 6 months than that of healthy people,and the difference is statistically significant(P﹤0.05).2.The incidence of abnormal density of vaginal flora,abnormality of microbial diversity,abnormality of dominant bacteria,leukocyte count of vaginal secretion >10/high magnification field of view,β-glucuronidase positive,acetylglucosaminidase positive,trichomonas vaginitis,Candida vaginitis,abnormal vaginal flora,vaginal microecological dysfunction,and incidence of mixed infection in women with HR-HPV infection more than 6 months was lower than that of healthy people,but the difference was not statistically significant(P﹥0.05).3.The incidence of normal vaginal microecology in women with HR-HPV infection more than 6 months was lower than that of healthy people,and the difference was statistically significant(P﹤0.01).Tip: The incidence of vaginal microecological imbalance in women with HR-HPV infection more than 6 months is higher than that in healthy people.In order to prevent the further development of the disease,we should actively use vaginal microecological test in women with HR-HPV infection more than 6 months,to find and treat the possible imbalance of vaginal microecology in time.