Structural Allogeneic Lyophilized Bone For Treatment Of Lumbar Tuberculosis

Objective:Retrospective analysis of structural allogeneic freeze-dried bone treatment of lumbar tuberculosis patients.Methods:During the period from March 2012 to July 2016,220 patients with lumbar tuberculosis underwent surgical treatment in our department,and of 198 patients with complete follow-up were enrolled in this study.There were 105 males and 93 females aged 44 ± 15 years old(16-80 years).168 cases are single-stage infection and 30 cases are 2-stage and more than 2 infections.129 patients underwent simple anterior surgery,52 underwent simple posterior surgery and 17 underwent anterior and posterior approaches.Evaluate neurological function,pain score,deformity correction,degree of fusion,fusion rate and complications.Results:Compared with preoperative and the final follow-up of all patients ESR,C-reactive protein was improved,the difference was statistically significant(P<0.05).Patients were followed up for 30±11 months.2 patients had fractures of the bone graft and 6 patients had recurrent tuberculosis.2 of them had sinus formation.The average preoperative JOA score was 17.0 ± 2.8 points,the average follow-up time was 24.8 ± 3.3 points,and the rate of JOA improvement was 65%.The preoperative Cobb angle was-1.1 ° ± 4.2 ° and 5.3 ° ± 2.7 °,4.1 ° ± 2.3 ° at follow-up and 6.0 ° postoperatively.The average length of orthopedic loss at the final follow-up was 1.2 °.There was a significant difference in Cobb angle at the last follow-up(P <0.05).ASIA grades had improved after treatment.X-ray evaluation of allogeneic lyophilized bone fusion time is 9.3±2.2 months,CT evaluation of fusion time 12.7±3.1 months.Assesed the Grade I patients by CT,59 cases had complete trabecular bone formation in the 78 cases,the positive rate 76%.Conclusions:On the basis of systemic anti-TB drugs,it is safe and feasible to treat lumbar tuberculosis with allogeneic lyophilized bone.