| Objective: to evaluate load the chemotherapy medicine HRZ calciumsulfate/poly amino acid rabbit lumbar tuberculosis kitchen of artificial boneremoval surgery of the imaging features of bone graft fusion.Methods: New Zealand big-eared rabbits,36, of which has been successfullyset up animal model of rabbit spinal tuberculosis and24only. Experimentalanimals in three groups: group A, the experiment model group; Group B, theexperiment model of the control group; Animal model of experimental rabbitspinal tuberculosis in24points into two groups at random. Group C and blankcontrol group. Three sets of lines are on the same terms and procedure spinaltuberculosis kitchen removing bone graft fusion, range of bone defect, implantloaded sanlian group A chemotherapy drug (INH, RFP and PZA) calciumsulfate/poly amino acids, artificial bone materials, B and C group of drug-loadingimplanted the calcium sulfate/poly amino acid artificial bone material. Onpostoperative day1,2,4,8and16go X-ray and reconstruction of CT and MRIexamination, evaluation of bone graft fusion.Results:16weeks after operation, the imaging examination showed in groupA and group C bone graft healing is similar, no significant differences in group Athan in group B bone graft healing effect is good.Conclusions: the triple chemotherapy medicine packing of artificial boneosteogenesis effect is obvious, has obvious bone reconstruction and filling function, can be used for reconstruction of bone defect after bone tuberculosislesions cleared the residual bone graft fusion. |
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