The Significance Of Blink Reflex In The Diagnosis And Prognosis Of Post-stroke Depression

Objective:This article is to observe the changes in the latency of Blink reflex(BR)after treatment with escitalopram oxalate in patients with PSD for 2 weeks,and to combine the Hamilton depression scale and NIHSS scores to explore the value of BR latency level in diagnosis and prognosis of PSD.Methods:Randomly selected patients with ischemic stroke clinically diagnosed in Neurology Inpatient Department of Affiliated Hospital of Yanbian University from September 2017 to February 2018,and divided them into stroke group(stroke,S group,n=57)meeting HAMD score<8 points,post-stroke depression group(PSD group,n=40)meeting HAMD score≥20 points.Another 37 healthy volunteers were normal control group(group N).The blink reflex examinations were performed respectively to observe the latency changes of the blink reflexes of the three groups.Simultaneous ischemic stroke treatment was given in the S group.The PSD group was treated with the conventional ischemic stroke plus escitalopram oxalate,followed by treatment for 2 weeks.The PSD group underwent blink reflex examination and compared the differences of the data.Statistical analysis was performed to examine the correlation among the blink reflex latency,degree of depression,and degree of neurologic deficit in the three groups of subjects.Results:1.The results of BR in the PSD group showed that the latency of R1,R2,and contralateral R2 was longer than that of the normal control group,and the difference was statistically significant(P<0.05).The results of the blink reflex examination in the stroke group showed that the latency of R1,R2,and contralateral R2 was longer than those of the normal control group,and the difference was statistically significant(P<0.05).The results of blink reflex latency in the PSD group were significantly different from those in the stroke group(P<0.05).2.In the PSD group,the HAMD scores before treatment were positively correlated with the latency results of R1,R2 and contralateral R2 before treatment(P<0.05).There was a positive correlation between HAMD scores and the latency results of Rl,R2 and contralateral R2 after treatment(P<0.05).The HAMD score after treatment was obviously lower than before treatment,with a significant difference(P<0.05).The latency of R1,R2 and contralateral R2 in the blink reflex after treatment was significantly shorter than that before treatment,and the difference was statistically significant(P<0.05).3.There was no correlation between NIHSS scores before treatment and blink reflex latency before treatment in the PSD group.There was no correlation between NIHSS scores before treatment and blink reflex latency(R1,R2,contralateral R2)before treatment in the PSD group.NIHSS scores after treatment in patients with PSD were positively correlated with R2 latency after treatment(P<0.01),and were not correlated with R1 and contralateral R2 latency.4.NIHSS scores in patients with stroke were positively correlated with Rl,R2,and contralateral R2 latency(P<0.05).There was no correlation between HAMD scores and blink reflex latency(R1,R2,contralateral R2)in the stroke group.Conclusions:1.After treatment with antidepressants in patients with post-stroke depression,BR latency was significantly shorter,and depression and severity of illness were improved.2.Through HAMD,NIHSS score and BR test,it can provide scientific basis for accurate diagnosis and prognosis evaluation of post-stroke depression.