The Analysis Of The Types Of The Seizures Of 2191 Children With Epilepsy And The Common Epilepsy Syndrome In Childhood

ObjectiveWe retrospectively analyzed seizure types of 2191 epileptic children on onset types and symptomatology of epilepsy syndrome to observe symptomatic characteristics of children with epilepsy.Methods1.Establishment of the epilepsy follow-up questionnaire:A follow up questionnaire was used to collects the basic information include physical examination,medical history data,auxiliary examination,drug treatment and curative effect and mental motor development of 2191 epilepsy children,who diagnosed at the pediatric neurology department of Shandong university in qilu hospital from January 2004 to January 2017.2.Data analysis;we analyzed seizure syndrome of all children with epilepsy.Epilepsy syndrome were classified according to age,seizure types,electroencephalogram characteristics,auxiliary examination,mental and motor development3.Follow-up time:All children were followed up for more than one year.4.Statistical methods:Data analysis of 2191 children with epilepsy was done using SPSS 19.0 software.Results1.There were 2191 children with epilepsy,1318 males and 873 females whereby male to female ratio was 1.51:1.The age of onset was 0～14 years,whereas children with age of 0～3 years old were 1307 cases,accounting for 59.7%,～6 years old 459 cases,accounting for 20.9%,～10 years old 301,accounting for 13.7%and 10 years old一124 cases,accounting for 5.7%.2.Among 2191 children,there were 1459 cases of non-epilepsy syndrome,and their distribution according to seizure types were as follows:(1)focal seizures were 784 cases,accounting for 53.7%,of which 689 cases(87.9%)had focal motor seizure and 95cases(12.1%)had focal non-motor seizures;(2)generalized seizures were 604 cases,accounting for 41.3%,of which 599 cases(99.2%)had generalized motor seizures and 5 cases(0.8%)had generalized non-motor seizures;(3)unknown-initially seizures were 65 cases,accounting for 4.5%,of which 62 cases(95.3%)had motor seizures and 3 cases(4.7%)were non-motor seizures;(4)6 cases their seizures were not classified.3.There were 732 cases out of 2191 children classified as epilepsy syndrome,accounting for 33.4%.The most common epilepsy syndromes seen were:benign epilepsy of childhood with centrotemporal spikes were 170 cases(23.2%),infantile spasm 132 cases(18.1%),benign infant epilepsy 116 cases(15.8%)and Lennox-Gastaut syndrome were 75 cases(10.2%);Other rare epilepsy syndromes total of 239 cases,accounting for 32.7%,including 3 cases of neonatal familial benign convulsions(0.4%),Ohtahara syndrome 26 case(3.5%),Dravet syndrome 13 cases(1.8%),febrile seizure plus 32 cases(4.5%),Panayiotopoulos syndrome 24 cases(3.3%),Doose syndrome 3 case(0.4%)and autosomal dominant nocturnal frontal lobe epilepsy 1 case(0.1%),late onset occipital lobe epilepsy 9 cases(1.2%),Continuous spike-waves during slow-wave sleep 3 cases(0.4%),Landau-Kleffine syndrome 2 cases(0.2%),childhood absence epilepsy 38 case(5.2%),frontal lobe epilepsy 52 cases(7.1%),temporal lobe epilepsy 32 cases(4.5%)and juvenile absence epilepsy 1 case(0.1%).Conclusion1.The onset of epilepsy gradually decreased with advance age,and highest occurrence within 3 years old,and its more in males than females.2.Various types of epileptic seizures,and focal seizures occurs more frequently than generalized seizures.3.In all cases,33.4%was classified as epilepsy syndrome.The most common epilepsy syndrome were benign epilepsy of childhood with centrotemporal spikes,infantile spasm,benign infantile epilepsy andLennox-Gastaut syndrome.