Clinical Study Of Lauromacrogol Injection Combined With Laser Treatment And Oral Propranolol Treatment Of Infantile Hemangioma

Objective: To study the hardener is gather cinnamyl alcohol foam injection combined with long pulse 1064 nm ND: YAG laser localized treatment with oral propranolol system treatment efficacy and safety of mixed Infantile Hemangioma differences,to explore safe and effective method for the treatment of mixed Infantile Hemangioma.Methods: Collected children with mixed infantile hemangioma from January 1,2016 to May 31,2017 in the dermatology department of the Affiliated Hospital of Guilin Medical College.According to the inclusion criteria,a total of 45 cases(50 lesions)were included,44 cases(49 lesions)were followed up,and 1 patient stopped treatment before the end of observation.Choose according to the will of the families of children.Of which is divided into Lauromacrogol foam sclerotherapy combined with long pulse 1064 nm ND: YAG laser localized treatment group,referred to as localized combination treatment group(32 cases)and oral propranolol treatment,referred to as systematic treatment group(12 cases).The Severity scale of Hemangioma Activity and Severity Index(HASI)was used to grade all children before treatment.After treatment began to 1 time per 1 month follow-up,follow up through diagnosis,palpation and colour to exceed to evaluate changes in tumors,sure to observe the end,according to the change of magnetic resonance imaging(MRI)results before and after the treatment curative effect evaluation.The difference in the treatment cycle was compared between the treatment period and the treatment cycle.The adverse reactions in the treatment of the two groups were observed and analyzed statistically.Results: SPSS 18.0 statistical software was used in this study,and the results were as follows.1,Using independent sample t test to compare the local joint severity cases in two treatment group,the difference was statistically insignificant(p>0.05),the illness severity of two groups of children was close;2,The change of contrast before and to the end of observation in children with MRI findings,using independent sample t test method to compare two groups of mean score,there was no statistically significant difference(p>0.05);3,When it comes to the time if the end of observation,the treatment time of localized combination treatment group is 3±1.586 months on average,systematic treatment group treatment cycle for an average of 6±0 months,using independent sample t test method to compare two groups of treatment duration,the difference was statistically significant(p<0.001),localized combination treatment group can achieve therapeutic goals in a shorter time;4,During the observation period,no serious adverse reactions were observed in both groups.Conclusion: Lauromacrogol foam sclerotherapy combined with long pulse 1064 nm ND:YAG laser local treatment of mixed infantile hemangioma with shorter time,good efficacy and short-term mild adverse reaction.However,due to the lack of sample size,the observation time was shorter,and larger samples and longer follow-up studies were needed.