Clinical Observation Of The Effects On Retention Enema With Kuijieling Ⅳ Combined With Mesalazine For Oral In Patients With Large Intestine Damp Heat Type Of UC

Objective:To observe the clinical effect of mesalazine[5-aminosalicylic acid(5-ASA)preparation]combined with Kuijieling Ⅳ retention enema on the treatment of large intestine damp-heat type UC,the mucosal status of colonoscopy,and the improvement of TCM syndromes Situation,and impact on CRP,FC levels.Methods:Forty patients with UC who met the inclusion criteria were included in the clinical observation plan and randomly divided into two groups.The treatment group(n=20):oral mesalazine(half the normal dose)combined with Kuijieling IV retention enema;control group(n=20):Normal oral dose of mesalazine;observation of clinical efficacy before and after treatment in both groups,mucosal recovery under colonoscopy,improvement of TCM syndromes,changes in CRP,FC levels.At the same time improve the blood,urine,stool routine,liver and kidney function safety indicators.All data obtained were statistically analyzed using SPSS19.00.Result:1.Clinical symptom relief effect:The total effective rate was 95%in the treatment group,75%in the control group,80%in the significant treatment group,45%in the control group,P<0.05,the difference was statistically significant,and the treatment group was clinical The mitigation effect was better than that of the control group.2.Comparison of clinical symptom scores:The clinical symptom scores of the two groups were significantly lower than those before treatment,P<0.05,the difference was statistically significant;the comparison treatment group between the two groups was better than the control group,P<0.05,the difference was Statistical significance3.The efficacy of colonoscopy:The baron endoscopic scores of the two groups were significantly lower than those before treatment,P<0.05,and the difference was statistically significant;the comparison between the two groups was better than that of the control group(P<0.05).Statistical significance4.Efficacy of TCM syndromes:The clinical symptom scores of both groups were significantly lower than those before treatment,P<0.05,and the difference was statistically significant;the comparison group between the two groups was better than the control group,P<0.05.Statistical significance5.TCM syndrome scores:The clinical symptom scores of both groups were significantly lower than those before treatment,P<0.05,the difference was statistically significant;the comparison group between the two groups was better than the control group,P<0.05,the difference was Statistical significance.6.Change of CRP and FC levels:After treatment,the CRP and FC levels in the two groups decreased.Compared with before treatment,the difference was statistically significant(P<0.05).In the comparison between groups,the treatment group reduced CRP,and the FC effect was better than the control group.Group,P<0.05,the difference was statistically significant.7.There was no obvious abnormality in blood and urine routine and liver and kidney function before and after treatment in both groups.Conclusion:The combination of mesalazine and Jieling IV retention enema in the treatment of large intestine damp-heat type UC can significantly improve the clinical efficacy,improve the clinical symptoms such as diarrhea,pus,diarrhea,etc.,and can obviously promote the healing of intestinal mucosal ulcers,especially the anal burning.The symptoms of TCM,such as heat,dry mouth and bad breath,have significant effects,and fewer adverse reactions occur.