Clinical Research On Retention Enema With Compound Phellodendron Liquid Treatment For Patients With Large Intestine Damp-heat Type Ulcerative Colitis

ObjectiveUlcerative col it is (UC) say again chronic nonspecific ulcerative colitis. The typical and clinical expression is abdominal pain, diarrhea,bloody mucopurulent stool and rectal tenesmus, etc. At present the disease cause and pathogenesis has not yet fully understood. The disease easi ly break out repeatedly with protracted course or suffer from cancers.It severely influences the quality of life,and so physical and mental health, so ranked stubborn disease by WHO. In recent years there is a significantly higher incidence of the disease in China. The western medicine used clinically such as aminosalicylic acid, glucocorticoids, antibiotics, immunosuppressive agents, etc. But there is side effects, precious drug cost, patients with poor compl iance. Recently many scholars discuss traditional Chinese medicine to cure ulcerative colitis in effective way, but these proprietary Chinese medicine is flexible and lack of uniform accepted methods of treatment. This study according to the Chinese medicine syndrome differentiation and treatment principle of ulcerative colitis to classify it, gives retention enema with compound phellodendron liquid treatment to patients with large intestine damp-heat type ulcerative colitis and observes the clinical efficacy, discusses the feasibility,efficacy and advantages of this treatment for providing the basis of its clinical application.Methods60patients with diagnosis of large intestine UC different patients, male28cases, female32cases, adopting the rule of random, were divided into two groups:30in treatment group and30in the control group. After statistics analysis, two groups of cases material in gender, age, course, illness state, colonoscopy mucosal lesions, there were no significant difference (p>0.05), be comparable.In the treatment group,100mL compound phellodendron liquid were given via retention enema, while in the control group the patients were given via retention enema with100mL metronidazole solut ion, gentamycin, dexamethasone, xi lei san such as mixed liquid instead of compound phellodendron liquid. The treatment group and the control group were both retention enema one time every day for15days in the night, then one time two days for the rest time in3months. After treatment,used statistical methods to compare two sets of clinical symptoms and signs, UC DAI, colonoscopy mucosal lesions curative effect, the comprehensive effect and Chinese Medicine comprehensive syndromes curative effect, etc.ResultsAfter treatment, the two groups of patients with clinical comprehensive curative effect were comparable. The treatment group’s total effectiveness96.67%, the control group’s total effectiveness76.67%,after statistics analysis, p<0.05, statistical significance was found between total clinical comprehensive curative effect, the treatment group was better than the control group;After treatment, the two groups of patients with UC DAI total score were comparable,the treatment group2.23±1.74, the control group4.73±2.45,after statistics analysis, p<0.01, significant difference,the treatment group was better than the control group in UC DAI curative effect;After treatment,all kinds of the clinical symptoms in the two groups were comparable, after statistics analysis, p<0.05, the treatment group was better than the control group in clinical symptoms curative effect; After treatment, the two groups of patients with colonoscopy mucosal lesions curative effect were comparable, after statistics analysis, p<0.05, the treatment group wae better than the control group in colonoscopy mucosal lesions curative effect. Two groups of patients after treatment of TCM syndrome curative effect were comparable, the treatment group’s total effectiveness93.33%, the control group’s total effectiveness73.33%,after statistics analysis, p<0.05, differences have statistical significance, the treatment group was better than the control group in curative effect of TCM syndrome.ConclusionThe study used the TCM compound phellodendri Liquid retention enema to treat large intestine damp-heat type ulcerative colitis, basing on Chinese medicine syndrome differentiation and treatment principle, and gave full play to the advantages of traditional Chinese medicine’s individual therapy. Through the retention enema this way, made solution direct to lesions, adequately protected, promoted to repair mucous membrane, cured ulcerative colitis. It is an effective and convenient with slight side-effects for controlling ulcerative colitis (UC).So it is worthy of further study and clinical application extensively.