Correlation Analysis Between Galactoin-3 And Coronary Heart Disease With Different Traditional Risk Factors Patients

Objective:At present,the more and more abundant CHD spectrum,and the more and more complex CHD subgroup.Then,there may be new characteristics among the various risk factors of CHD,especially between the new ones and the traditional ones.Our study mainly aim is to explore,when CHD with different traditional risk factors(hypertension,diabetes,dyslipidemia and smoking),the correlation between new risk factor Gal-3and thses.Methods:Population based case-control study.The data of 264 patients were collected from October 2016 to August 2017 in the Ruikang Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,who accepted coronary angiography(CAG)during hospitalization.All data were analyzed by SPSS22.0.CAG examination as the"gold standard"diagnosed CHD.According to CAG results,patients were grouped:non-CHD patients as the control group,CHD patients as the case group(CHD group).Then by CHD with different traditional risk factors as standard,the case group was divided into relevant subgroups,and the correlation between Gal-3 and CHD with different traditional risk factors was analyzed.Results:1.The case group patients were higher than the control group in the aspects of hypertension,diabetes,dyslipidemia,smoking,Gal-3,hsCRP,and LDL-C(P<0.05,n=243).2.Of the 243 patients underwent Logistic regression analysis showed that age(OR:1.079,95%CI:1.037~1.123),Gal-3(OR:1.508,95%CI:1.303~1.750),hsCRP(OR:1.074,95%CI:1.010~1.141),and LDL-C(OR:1.775,95%CI:1.775~5.370)were independent predictors of CHD(P<0.05).Further analysis of ROC curve indicated that Gal-3 had the highest predictive value for the onset of CHD.Its area under the ROC curve was0.82(P<0.01).When the serum Gal-3 level was more than 9.00 ng/ml,the sensitivity of occurrence CHD was 73%and the specificity was 74%.3.When the severity of coronary artery was judged by the modified Gensini score,the more serious coronary artery stenosis was,the higher serum Gal-3、hsCRP level(P<0.01,n=243),but only the difference of Gal-3 between any two groups was statistically significant(P<0.01).4.In the Spearman correlation analysis of CHD with tradional risk factors 153 cases,we found that Gal-3 and hsCRP were positively correlated with diabetes,but the correlation between Gal-3 and diabetes was the strongest:a significant high correlation(r_s=0.827,P<0.01).There was a positive correlation between Gal-3 and CHD with smoking,but the correlation was very weak(r_s<0.3,P<0.05).There was a positive low correlation between hsCRP and CHD with hypertension(r_s=0.421,P<0.05).5.Analysis of CHD with risk factors 153 cases showed that the serum Gal-3 level of CHD with diabetes was higher than without diabetes(11.828±3.620,10.405±4.003,P<0.05).And finally,according to the fasting blood glucose(FBG)severity,the serum Gal-3 level of CHD with diabetes66 cases was further analyzed.We found that Gal-3 was also a positive correlation with FBG:as the severity of FBG increased,correspondingly,the Gal-3 level of patients increased too(6.877±1.519,11.616±2.079,15±2.488,P<0.01).Conclusions:1.The serum Gal-3 level of CHD patients was higher than non-CHD patients,and the more serious coronary artery stenosis,correspondingly,the higher serum Gal-3 level.The serum Gal-3 level was an independent risk factor for the occurrence of CHD,and it could predict the possibility of occurrence CHD.2.When CHD combined with different traditional risk factors,Gal-3 had only a good correlation with CHD combined with diabetes,and moreover,there was also a positive correlation between the FBG severity and the serum level of Gal-3.