The Correlation Analysis Between Serum Galectin-3 Level And Characteristics Of Coronary Plaques In Patients With Coronary Heart Disease

ObjectiveTo analyze the characteristics of the coronary artery atherosclerotic plaques tissues of the Coronary Heart Disease(CHD) patients through the virtual histology-intravascular ultrasound, and study the correlation with the coronary atherosclerotic plaques and serum Galectin-3.Methods1、We selected 257 patients with CHD (stable angina group(n=85)and acute coronary syndrome group(n=172)) as study object and they will be examined by coronary angiography and diagnosed as CHD.2、Patients diagnosed as CHD will be examined by intravascular ultrasound further, and recorded the gray-scale and virtual histology image data.3、We tested the serum Galectin-3 level and hypersensitive C-reactive protein level in patients with CHD.4、We analyzed the correlation with intravascular ultrasound results and the coronary atherosclerotic plaques characteristics.Results1、We found that no obvious differences existed in general information among the three study groups.2、The VH-IVUS showed the study:the vascular remodeling index, the proportion of necrotic core, plaque eccentricity index in ACS group,which was higher than these in the SA group. The difference showed statistically significance.3、Galectin-3 in ACS group is higher obvious than Galectin-3 in the SA group and control group, The difference was statistically significant.4、There was a positive correlation between Galectin-3 and the proportion of necrotic core、vascular remodeling index, plaque eccentricity tissue index in the ACS group.Conclusion1、Coronary atherosclerotic plaques in ACS are mostly made of necrotic core、 partial plaques, Coronary atherosclerotic plaques in SA are mostly made of fibrous tissue or fibro-fatty tissue.2、There was a obviously positive correlation between Galectin-3 and the proportion of necrotic core、vascular remodeling index, plaque eccentricity tissue index in the ACS group.