Comparative Analysis Of Clinical Epidemiology And Pathological Features Of 965 Patients With Lung Cancer

Objective:The epidemiological characteristics of lung cancer have changed with the change of region and time.This study collected clinical data of patients with primary bronchogenic carcinoma admitted to the Affiliated Hospital of Yanbian University and compared their epidemiological and pathological features.Understanding the development and changes of lung cancer in the past 10 years in this region provides a theoretical basis for the prevention and treatment of lung cancer.Methods:A total of 965 clinical cases with lung cancer admitted to the Affiliated Hospital of Yanbian University were collected.Among them,318 were from 2004 to 2006,and 647 from 2014 to 2016.The patient’s gender,nationality,age,smoking history,family history,pathological type and preferred treatment of the patients in those two time periods were studied retrospectively.The data were statistically analyzed by SPSS17.0 software,P<0.05 was considered statistically significant difference.Results:1.The proportion of lung cancer among patients over 60 years of age was highest between 2004-2006 and 2014-2016.The composition ratio of elderly patients with lung cancer(63.5%)was higher in 2014-2016 than in 2004-2006(57.0%).The difference was statistically significant(P<0.05).2.The composition ratio of smoking lung cancer patients in 2014-2016 was higher than that in 2004-2006,and the difference was statistically significant(P<0.05).3.The composition ratio of patients with family history of lung cancer from 2014 to 2016 was higher than that of 2004-2006,and the difference was statistically significant(P<0.05).4.Compared between 2004-2006 and 2014-2016,the proportion of squamous cell carcinoma in the pathological type of lung cancer patients decreased,and the ratio of adenocarcinoma and small cell carcinoma increased.The difference was statistically significant(P<0.05).5.Comparison between 2004-2006 and 2014-2016:Male,Han people,non-smokers,and lung cancer patients over 60 years old all showed a decrease in the squamous cell component ratio,an increase in the ratio of adenocarcinoma and small cell carcinoma,and there were differences.Statistical significance(P<0.05).6.The proportion of squamous cell carcinoma was highest among smoking and male lung cancer patients in 2004-2006 and 2014-2016.The non-smoking and female lung cancer patients had the highest ratio of adenocarcinoma,and the differences were statistically significant(P<0.05).7.Targeted drug treatment was used more frequently between 2014 and 2016,the proportion of untreated patients decreased,and the combination of multiple treatments increased.Conclusion:1.Comparison between 2004-2006 and 2014-2016:The proportion of the elderly,those who have a history of smoking,and those with a family history of lung cancer all show an increase in the latter compared to the former.2.The pathological type of lung cancer was mainly changed from squamous cell carcinoma of 2004-2006 to adenocarcinoma of 2014-2016,and the proportion of small cell carcinoma increased.3.Comparison between 2004-2006 and 2014-2016:Male,Han people,non-smoking history,and lung cancer patients over 60 years of age showed pathological types of squamous cell decline,and the proportion of adenocarcinoma and small cell carcinoma increased.4.From 2004 to 2006 and 2014 to 2016,squamous cell carcinoma was the main pathological type in males and smokers.Adenocarcinoma was the main pathological type in females and non-smokers.