| Objectives:To retrospectively analyze the clinical data of 15,967 primary lung cancer patients who underwent surgical treatment in the Department of Thoracic Surgery,Yunnan Cancer Hospital from 2013 to 2022,to understand the epidemiological characteristics of lung cancer surgery patients in Yunnan in the past 10 years,and to provide scientific reference for the prevention and treatment of lung cancer in Yunnan.Methods:The clinical data of patients who underwent surgery for lung cancer in the thoracic surgery department of Yunnan Cancer Hospital from 2013 to 2022 were collected,and the pro-epidemiological characteristics such as general data,surgical information,TNM stage,and pathological typing of lung cancer were statistically analyzed.Results:1.A total of 15,967 cases were collected,and the number of cases increased rapidly after 2018.2.There were 7,389 male cases and 8,578 female cases,and the male to female sex ratio fluctuated between(0.68-1.61:1),with differences in the male to female sex composition in different years(P<0.01).3.The median age was 56(49,63)years,with the highest proportion of patients in the age group of 50-59 years,and the proportion of patients under 60 years old was increasing year by year since 2017,with differences in the age composition between years(P<0.01).4.The median BMI was 22.76(20.76,24.91)kg/m~2,and the highest proportion of lung cancer surgery patients(59.5%)had normal BMI(18.5-23.9 kg/m~2).There was a difference in BMI composition between years(P<0.01).5.Qujing City with 6145 cases(38.5%)and Kunming City with 3448 cases(21.6%)were the top two regions in the distribution of the number of cases,and there were differences in regional distribution by year(P<0.01).29.3%of patients in Yunnan Province were from Xuanwei and Fuyuan regions(4351 cases).6.Smoking patients 4483 cases(28.1%)and non-smoking patients 11456 cases(71.9%),the proportion of smoking patients decreased from 33.5%to 21.2%,and there were differences in the distribution of smoking in different years(P<0.01).7.There were 9354 cases(58.6%)of right lung cancer,6480 cases(40.6%)of left lung cancer,and 133 cases(0.8%)of double lung cancer.The distribution of single lung lobe lesions was:upper lobe of the right lung(28.2%),middle lobe of the right lung(6.3%),lower lobe of the right lung(19.8%),upper lobe of the left lung(23.0%),and lower lobe of the left lung(15.6%),with differences in the composition of incidence sites by year(P<0.01).8.The proportion of thoracoscopic surgery increased from 30.8%to 96%,with9793 single-port thoracoscopic surgeries(61.3%),and there were differences in the composition of surgical techniques in different years(P<0.01).9.10245 cases(64.2%)of lobectomy,2745 cases(17.2%)of lung wedge resection,1944 cases(12.2%)of segmental lung resection,and the proportion of lobectomy decreased from 83.1%to 46.1%,and there was a difference in the composition of surgical techniques in different years(P<0.01).10.1004 cases(6.4%)in stage 0,10,191 cases(63.8%)in stage I,1832 cases(11.5%)in stage II,2240 cases(14.0%)in stage III,and 694 cases(4.3%)in stage IV.The proportion of stage 0-Ⅰincreased from 43.5%to 82.8%,and the proportion of stage II-Ⅳdecreased from 56.5%to 17.2%,and the composition of TNM stages differed by year(P<0.01).There were differences in the composition of TNM stages in different years(P<0.01).11.There were 13,461 cases(84.3%)of adenocarcinoma,1,894 cases(11.9%)of squamous carcinoma,117 cases(0.7%)of small cell carcinoma,52 cases(0.3%)of large cell carcinoma,and 443 cases(2.8%)of others.The proportion of adenocarcinoma increased from 75.6%to 88.3%,and the proportion of squamous carcinoma decreased from 21.5%to 8.6%,with differences in the composition of pathological types by year(P<0.01).Among adenocarcinomas,60.9%were female;among squamous carcinomas,90.6%were male(P<0.01).The peak incidence of adenocarcinoma was 50-59 years and the peak incidence of squamous carcinoma was60-69 years(P<0.01).The proportion of squamous carcinoma with BMI of low weight(<18.5 kg/m~2)or normal(18.5-23.9 kg/m~2)was higher(P<0.01).The proportion of adenocarcinoma was 91.9%in Xuanwei and Fuyuan and 81.1%in other regions(P<0.01).The smoking rate was 65.9%in patients with squamous carcinoma and 22.3%in patients with adenocarcinoma(P<0.01).The proportion of patients with stage 0-Ⅰadenocarcinoma was 76.3%,and the proportion of patients with stage II-Ⅲsquamous carcinoma was 64.1%(P<0.01).Squamous carcinoma was more prevalent in the left lung(P<0.01).Conclusion:1.The number of lung cancer cases treated by surgery in Yunnan cancer hospitals increased year by year from 2013 to 2022,with a large increase in the last 5 years,and adenocarcinoma was the main pathological type of lung cancer in Yunnan.2.The number of female lung cancer patients exceeded that of males after 2017,and adenocarcinoma was the most common among females and squamous carcinoma was the most common among males.3.The age of lung cancer incidence in Yunnan region showed a trend toward younger age,with the peak incidence of adenocarcinoma at 50-59 years and squamous carcinoma at 60-69 years.4.The average BMI of lung cancer population is lower than that of normal population,and the BMI of patients with squamous carcinoma is lower than that of other pathological subtypes.5.Qujing city(especially Xuanwei and Fuyuan areas)has the highest incidence of lung cancer in Yunnan province,and the proportion of adenocarcinoma in this area is higher than that in other areas.6.The smoking rate of lung cancer population is decreasing,and squamous carcinoma is commonly found in smokers.7.The sites of lung cancer incidence from high to low are upper lobe of right lung,upper lobe of left lung,lower lobe of right lung,lower lobe of left lung,and middle lobe of right lung,but squamous carcinoma is more frequent in upper and lower lobe of left lung.8.Thoracoscopic surgery is increasing year by year,and single-hole thoracoscopy has become the preferred surgical technique.9.The proportion of lobectomy decreases and the proportion of sublobectomy increases.10.The proportion of stage 0-Ⅰlung cancer is gradually increasing,and the proportion of stageⅡ-Ⅳlung cancer is gradually decreasing.Adenocarcinoma was mostly seen in stage 0-Ⅰpatients,and squamous carcinoma was mostly seen in stageⅡ-Ⅲ. |
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