Analysis Of Pathological And Clinical Features Of Liver Tissue In 250 Patients With Chronic Hepatitis B

ObjectiveTo investigate the relationship between gender,age,serum ALT and HBV-DNA levels,1iver stiffness measurement and the pathological grading and staging of liver tissue among patients with HBeAg negative chronic hepatitis B(CHB).MethodsThe clinical data of 250 patients with chronic hepatitis B were analyzed retrospectively,in the aspects of serum HBV-DNA loads,ALT,1iver stiffness measurement,demographic data and liver histopathology.ResultsAmong 250 cases of CHB,There was a significant difference in the proportion of liver inflammation grade≥G2 between HBeAg negative group and HBeAg positive group(P<0.05),but there were no significant differences between the two groups of fibrosis stage≥S2(P>0.05);When the liver inflammation grade≥G2,there was a significant difference in the proportion of age≥40,ALT≤1*ULN and HBV-DNA loads≤1000IU/L between HBeAg negative group and HBeAg positive group(P<0.05),while fibrosis stage≥S2,there were statistically significant differences in the proportion ofage≥40,ALT>2*ULN and HBV-DNA loads>100000IU/L between HBeAg negative group and HBeAg positive group(P<0.05);In HBeAg negative group when ALT > 2*ULN and HBV-DNA loads > 100000IU/L,there were statistically significant differences in the proportion of liver inflammation grade≥G2 and fibrosis stage≥S2 between HBeAg negative group and HBeAg positive group(P<0.05).When age≥40,therewere statistically significant differences in the proportion of liver fibrosis stage≥ S2 between HBeAg negative group and HBeAg positive group(P<0.05);Liver fibrosis stages displayed a positive correlation to liver inflammation grades,age,serum ALT,HBV-DNA loads and the mean stiffness.ConclusionWith the variation of age,serum ALT,HBV-DNA loads,liver inflammation and fibrosis of HBeAg negative patients with CHB aggravated at different extent.Furthermore liver fibrosis stages displayed a positive correlation to age,serum ALT,HBV-DNA loads and the mean stiffness.