| Professor Xu Rongqian as a famous pediatrician,is the fifth batch of national famous old Chinese medicine physician,and is also fourth batch of famous old Chinese medicine physician in Beijing.He studied from his father Xu Shaoen in early years and modeled after Professor Liu Bichen,who was know as "capital infantile king" and among the first national 500 famous Chinese medicine experts in 1990.This paper is divided into two parts to introduce Professor Rongqian Xu’s academic thought and clinical experience as well as to sum up professor Rongqian Xu’s Five-herbs Shenyan Decoction in treating chronic glomerulonephritis by systematic analysis of 80 clinical cases.Part One--Professor Rongqian Xu ’s Academic Thought and Clinical ExperienceIn the first part,the process of how professor Rongqian Xu became a State-level Famous Doctor(SFD)of Traditional Chinese Medicine(TCM)is reviewed.The process included family school cultivation,classical literature reciting,systematically school education,multiple study,preaching and teaching as well as theory conclusion.Eventually Professor Rongqian Xu becomes a TCM Pediatrics expertIn the second part,Rongqian Xu ’s clinical theory is emphasized.Professor Rongqian Xu has been a TCM doctor for more than 50 years and Shaoyang Doctrine(SD)was formed gradually,which together with Combination of Treatment from Liver-gallbladder and Treatment from Lungs(CLL)becomes the core theory of Professor Xu’s medical characteristics in treatment of pediatric diseases.Meanwhile,a relatively completed academic ideological system of Shaoyang School was initially formed.Professor Xu summarized the children Shaoyang Doctrine,including contents of Pure Yang,Shaoyang domains pivot,and Little Yang-Little Yin theory,also Pure Yang is not totally Yang and little Yin is not Yin insufficiency has been discussed.In the third part,clinical applications which best reflect the academic theory and experience of Professor Xu are elected.A lot is mature experiences are systematically summarized by 7 diseases and 3 prescriptions.Part two-Research on Treating Chronic Glomerulonephritis due to spleen and kidney qi deficiency in Five-herbs Shenyan DecoctionObjective:To summarize the clinical experience of Professor Xu and evaluate the clinical efficacy and security objectively of in Treatment of chronic Glomerulonephritis due to spleen and kidney qi deficiency.The mechanism of FSD in treating chronic Glomerulonephritis is also explored by observing the changes of chemical indicators before and after treatment.Methods:A total of 80 cases of patients diagnosed as chronic glomerulonephritis(spleen qi deficiency syndrome)in Dongzhimen Hospital,Beijing University of Chinese Medicine were collected and observed from May 2014 to OCT 2016.The patients were divided into treatment group(40 cases)and control group(40 cases)in accordance with a randomized controlled parallel principle.The duration of treatment was 3 months.The control group were given western medicine while treatment group was on the basis of western medicine plus modified FSD.Observe adverse reactions and changes of TCM syndrome,clinical symptoms and record the score,clinical and biochemical indices(urine,renal function,24-hour urinary protein excretion)before and after treatment.Result:1.No significant difference between two groups in age,gender,disease duration,symptom score and associated laboratory aspects before treatment(P>0.05).Two groups are comparable.2.The total effective of treatment group(85.00%)is significantly higher than control group(42.50%)when evaluating of the efficacy of the two groups of patients(P<0.01).3.Comparison in terms of TCM syndrome score:the treatment group symptom scores decreased while the control group symptom scores raise after treatment.There is a statistically significant difference(P<0.01)in aspect of symptom scores before and after treatment.Between the two groups after treatment,symptom scores compared with significant difference(P<0.05).The efficacy of symptom scores is higher in treatment group than the control group,with significant difference(P<0.05).Fatigue,nocturia,waist and knee pain and other symptoms were improved better in treatment group than in the control group after treatment,the difference was statistically significant(P<0.05).4.Comparison in terms of biochemical indices:urinary protein,urine occult blood reduced more efficiently in treatment group than the control group.with significant difference between groups(P<0.01).24h urinary protein in both treatment group and the control group decreased(P<0.01),and there is significant difference inside treatment group(P<0.05).renal function reduced more efficiently in treatment group than the control group,with significant difference between groups(P<0.05).renal function in both treatment group and the control group decreased(P<0.05),and there is significant difference inside treatment group(P<0.05).5.Adverse reactions:no significant adverse reactions was found in the treatment group.5 cases of cough and 3 cases of headache were occurred due to drug reaction in control group.The symptoms relieved after given symptomatic treatment.No patients withdrawn in the process.No significant side effects and dysfunction in liver and kidney was observed.Conclusion:Clinical efficacy and security of FSD in treating chronic glomerulonephritis due to spleen and kidney qi deficiency is verified,particularly when modifying the doctrine in accordance with different symptoms and promoting the physical function in a perspective of holism.Clinically,consolidating essence and dredging orifices of nasopharynx are emphasized.Clearing heat and removing dampness,promoting qi and blood circulation and removing stagnation are also important to ensure the normal function of the body and let external evil out.FSD could significantly improve patients’ symptoms as fatigue,nocturia and edema.Patient’s proteinuria,hematuria can be significantly reduced and renal function will be stabled so that progression of chronic kidney disease will be slowed. |
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