Clinical Study Of Vitamin D And Different Allergens In Patients With Moderate To Severe Allergic Rhinitis

Objective:By comparing moderate and severe allergic rhinitis in patients with normal crowd allergens in the serum of 13 kinds of serum vitamin D level percentage,preliminary discussion of vitamin D for allergic rhinitis immunological mechanism;The effects of common serum allergens on the symptoms and quality of life were analyzed,and the results were also provided for the prevention and treatment of allergic rhinitis.Methods:According to the inclusion criteria,exclusion criteria and classification of severity of allergic rhinitis diagnostic criteria in 130 patients with ultimate collection eligible-as the experimental group,severe allergic rhinitis patients healthy check-up eligible 65 cases as control group.Using enzyme-linked immunosorbent experimental detection of serum25(OH)D levels,and the experimental group of 13 kinds of serum allergen is divided into four groups,an inadequate vitamin D deficiency compared with controls,the percentage of three phase and appropriate level.A visual analogue scale(VAS)and nasal conjunctivitis questionnaire(RQLQ)were used to evaluate the two common allergens from ragweed and household dust mites.Results:1.There was no statistically significant difference in serum vitamin D between the experimental group and the control group(P > 0.05)The percentage of vitamin D defficiency in the experimental group was statistically significant compared with the control group(P<0.05).There was no significant in vitamin D in the experimental group compared with the control group(P>0.05).2.In four groups of serum allergen,the experimental group of ragweed(compositae ragweed),household dust mites(dust mites),shrimp/prawn,penicillium notatum/branch spore aspergillus/chain spore mold,mildew/smoke compared with control group,the lack of vitamin D deficiency and the percentage is higher than control group,the difference was statistically significant(P < 0.05).There was no statistically significant difference between the other 9 variables and the control group(P>0.05).The rest 9 kinds of allergen compared with the control group was no significant difference(P>0.05).3.(1)Results of various symptoms of VAS showed that the nasal symptoms of the ragweed group were higher than those in the household dust mite group,and the difference was statistically significant(P < 0.05).There was no statistically significant difference in ocular symptom score(P > 0.05).There was no statistically significant difference between the sexes in the two groups(P>0.05).(2)The evaluation results of each project of RQLQ showed that there was no significant difference between the two groups(P>0.05).In the two groups,the RQLQ score of the ragweed group was higher than that in the household dust mite group,and the difference was difference was statistically significant(P < 0.05).There was no significant difference in the evaluation results of the other projects(P>0.05).Conclusion:1.The average levels of serum 25(OH)D may not directly represent the relationship between vitamin D and moderate to severe allergic rhinitis.2.Vitamin D deficiency may have some negative effects in the immune dynamic balance of moderate to severe AR patients.3.There was a difference in the symptoms of patients with moderate to severe AR caused by ragweed and household dust mites,and the nasal symptoms of the patients with ragweed were more severe.There was no significant difference in the quality of life of patients with moderate and severe AR patients.