Analysis Of Dermatophagoides Farina Drops In The Treatment Of Allergic Rhinitis In Children Sensitized By Dust Mites Combined With Different Allergens

Objective: Research on the clinical efficacy and security of standardized dust mite drops sublingual immunotheray(SLIT)for allergic rhinitis(AR)in children with dust mite combined with different allergen allergy,which provides a preliminary basis for subsequent in-depth study on the treatment of Allergic Rhinitis.Method: Children were selected with AR who underwent SLIT in the Department of Otolaryngology-Head and Neck Surgery of Lufeng People’s Hospital from July2018 to December 2019 in the outpatient clinic.According to the inclusion,exclusion criteria and the serological test results(hereinafter referred to as the ingestion group),152 children with AR who underwent SLIT were divided into dust mite combined with inhalant allergy group(hereinafter referred to as inhalant group)and dust mite combined with ingestive allergy group.Comparing the differences between the clinical outcomes and incidence of adverse effects through the pre-treatment and 2-year post-treatment symptom scores(TNSS),medication scores(TMS)and visual analog scale scores(VAS scores)of the children in both groups.Result: After 2 years of follow-up,4 cases in the inhalation group withdrew voluntarily due to the patients’ families and various reasons,and 2 cases were lost.72 cases were completed in the inhalation group,of which 52 cases(72.2%)were male and 20 cases(27.8%)were female.5 cases in the ingestion group withdrew voluntarily due to the patients’ families and various reasons,and 3 cases were lost.66 cases were completed in the ingestion group,of which 45 cases(68.2%)were male and 21 cases(31.8%)were female.There were no significant differences in the sex and age composition between the two groups(P> 0.05).The two groups showed no statistically significant differences in TNS before treatment,TMS,and VAS(P> 0.05).After 2 years of treatment,there was a statistically significant difference between the TNSS,TMS and VAS of children in the two groups compared with those before treatment(P < 0.05).However,there was no significant difference between the two groups(P > 0.05).During the treatment period,only 15 cases(9 cases in the inhalation allergy group and 6 cases in the ingestion allergy group)had minor adverse reactions.However,there was no significant difference between the two groups.(P> 0.05).Conclusion: Standardized dust mite drops showed long-term efficacy in children with AR in both the inhalation and ingestion groups,but no significant differences between the two groups.