| Objective: To retrospectively analyze the distribution and drug resistance characteristics of 205 cases of neonatal septicemia in neonates and neonatal intensive care units of the First Affiliated Hospital of Xinjiang Medical University,so as to provide scientific basis for the treatment of septicemia.Method: Positive cases of neonatal blood collected from January 1,2007 to December 2016 in Xinjiang Medical University First Affiliated Hospital and newborn ICU were cultured,record the gestational age,gender,weight,time of onset,the results of blood culture and drug sensitivity analysis results and outcomes,according to gestational age were divided into preterm and full-term infants,according to the weight for very low birth weight infants,low birth weight infants and children aged 2500 g,according to early onset sepsis,late-onset sepsis onset time.Result: 1.Of the 205 cases reviewed,11 were premature,33 were full-term,49 were full-term,95 were early-onset sepsis and 110 were late-onset sepsis.50 cases of ultra-low birth weight+ very low birth weight,67 cases of low birth weight and 88 cases of ?2500g newborn.2.Gram-negative bacteria accounted for 60.4%(124/205),Gram-positive bacteria accounted for 35.1%(72/205)and fungi accounted for 3.4%(7/205)in our hospital neonatal sepsis blood culture results.The main pathogenic bacteria were 33.1%(68/205)of Klebsiella pneumoniae,13.6%(28/205)of Escherichia coli,17.5%(36/205)of Staphylococcus epidermidis and 6.8% of Staphylococcus aureus(14 / 205),Staphylococcus aureus 6.8%(14/205),Acinetobacter baumannii 10.2%(21/205),Candida albicans 2.9%(6/205),Candida tropicalis 1.4%(3/205).3.There were 95 bacterial strains and 32 G + strains in early sepsis,accounting for 33.6%(136/95)and 63 G-strains,accounting for 66.3%(63/95).There were 110 bacterial strains and 40 G + strains in late-onset septicemia,accounting for 36.36%(40/110),61 strains of G-bacteria,accounting for 55.45%(61/110)and 9 fungi 8.1%(9/110).There was a statisticallysignificant difference in the constituent ratio between G + bacteria and fungi in early onset and late onset sepsis(P <0.05),but no significant difference in G-bacteria(P> 0.05).4.Gram-positive bacteria to penicillin,erythromycin and tetracycline resistance rate is very high,the first and second generations of cephalosporin resistance rates were more than70%,but vancomycin and linezolid did not find resistant strains.Gram-negative bacteria not only for cephalosporin first and second generation of higher resistance rate,resistance rate of three generations of cephalosporins was also significantly higher,meropenem,imipenem no drug resistance.At present,fungi are not found to be resistant to common antifungal drugs.In conclusion:1.Our hospital pathogens to Gram-negative bacteria,Klebsiella pneumoniae which accounts for the majority of the incidence.2.Preterm children as the main incidence of the crowd.3.Early onset sepsis to Escherichia coli,coagulase-negative staphylococci mainly late-onset sepsis with Klebsiella pneumoniae based.4.The main G + bacteria and G-bacteria showed common resistance to common antibiotics,high sensitivity to carbapenems and glycosides antibacterials;fungi commonly used antifungal drugs found no resistance. |
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