Clinical Analyses Of 692 Cases Of Neonatal Sepsis

Objective:To study the positive rate of blood culture and main pathogen distribution in neonates with clinically suspected sepsis. And to study the clinical characteristics between early and late neonates with sepsis.Method::The clinical data of 692 patients with neonatal sepsis were retrospectively analyzed. Pathogens and complications were compared between early neonates (group 1) and late neonates (group 2).Results::In 692 patients with clinical diagnosis of neonatal sepsis, positive blood cultures were found in 11.42%. In neonates with positive blood cultures,83.53%were Gram positive bacteria. Coagulase-negative staphylococci were found in 68.24%of total positive culture. Gram negative bacteria were 14.12%and Fungi were 2.35%. There are no difference in pathogens distribution between early and late neonatal sepsis(P> 0.05). The most common complication is respiratory tract infections, then skin infections and intracranial infections. There are significant difference in infection rates among GI tract, CNS, skin and urinary system(P<0.05). Patients with neonatal sepsis usually accompanied by hemolytic disease, congenital heart disease, Cranial hematoma, intracranial hemorrhage, asphyxia.Conclusion:The positive rate of blood culture is not very high in neonates with clinical suspected sepsis. Gram positive bacteria, especial the Coagulase-negative staphylococci, are the main pathogens in neonatal sepsis. Neonatal sepsis usually related with local infection. Late neonatal sepsis closely related to the GI tract, CNS, skin and urinary infections.