| Objective:(1)Observation of huatantongluo on acute cerebral infarction(wind phlegm and blood stasis syndrome)changes of serum hs-CRP、 Hcy levels of patients,to further explore the mechanism of principle;to investigate huatantongluo prescription medication safety and clinical efficacy,in order to use TCM treatment method for wind phlegm and blood stasis for acute cerebral infarction the targeted drug treatment for huatantongluo in treating acute cerebral infarction(wind phlegm and blood stasis syndrome)to provide more theoretical basis for.(2)To observe the two acute cerebral infarction group(ACI)in patients with serum high sensitivity C-reactive protein(hs-CRP)and homocysteine(Hcy)concentration,the National Institutes of Health Stroke Scale(NIHSS),activities of daily living(ADL)、 disease class integration(DCI),TCM syndrome integration(TCMSI)changes,effects of huatantongluo on acute cerebral infarction in patients with serum hs-CRP、Hcy levels,to further explore the pathogenesis of acute cerebral infarction in the pathogenesis.To provide more clinical data for the treatment of acute cerebral infarction.Methods: in the hospital of Guangxi University of TCM affiliated Ruikang Hospital of neurology ward from January 2017 to January 2018 in accordance with the inclusion criteria of acute cerebral infarction(wind phlegm and blood stasis syndrome)in patients with 94 cases,divided into two groups randomly,the control group was treated with western medicine comprehensive treatment;treatment group(Western medicine comprehensive treatment + Huatan Tongluo Decoction),into the group after the two groups were compared at baseline,no significant difference test P > 0.05,comparable.To observe the clinical effect of continu ous treatment,the two groups after 2 weeks of TCM syndrome,NIHSS,ADL,DCI,TCMSI,hs-CRP,Hcy serum concentration change,the comprehensive evaluation of huatantongluo clinical efficacy and serum hsCRP and Hcy in acute cerebral infarction part principle,for further research to provide scientific data.Result:(1)comparison of NIHSS score and clinical effect(1)The two groups before and after treatment NIHSS score group comparison were decreased with statistical significance P < 0.01 differences,said two groups of neurological deficits were improved;the differe nce between the two groups was statistically significant P<0.05,show that the NIHSS score after treatment were significantly lower than the control group,the nerve function improved significantly compared with the control group.(2)The treatment group of 2 cases invalid,14 cases improved,26 cases of significant progress,5 cases were cured,effective rate was 95.7%;the control group of 5 cases invalid,23 cases improved,17 cases of significant progress,2 cases were cured,89.4% effective,by rank sum test(U=749,Z=-2.558,P< 0.05)two groups clinical differences have statistical significance,the effective rate of the treatment group than the control group,suggesting that the clinical efficacy of the treatment group than the control group.(2)comparison of TCM syndrome score and the curative effect of TCM Syndrome(1)The two groups before and after treatment of TCM syndrome score in comparison group were decreased P < 0.01,said the TCM syndromes were improved;HU treatment between the two groups had statisti cally significant difference P < 0.05,shows that after treatment,TCM syndrome score was significantly lower than the control group,the TCM symptoms improved significantly compared with the control group.(2)The treatment group of 1 cases invalid,18 cases improved,22 cases of significant progress,6 cases were cured,the total efficiency of 95.7%;control group 7 cases,24 cases invalid,16 cases of significant progress,progress,0 cases recovered,the efficiency is 85.1%,the rank sum test(U=723.5,Z=-3.136,P < 0.01)difference have statistical signifi cance,the treatment group was significantly higher than the control group,treatment group showed that the curative effect of TCM syndrome is better than that of control group.(3)comparison of ADL score(1)The ADL scores in the two groups before and after treatment were compared by t test(t=-19.146,t=-13.984;P < 0.01),the difference was statistically significant,suggesting that two groups of daily living a bility improved after treatment.(2)The comparison between the two groups after the treatment of the two groups was compared with the t test(t=13.356,P < 0.01).The difference was statistically significant,suggesting that the treatment group was better than the control group in improving the patient’s daily life ability.(4)an integral comparison of diseases(1)In the two groups before and after treatment,the score of disease integration group was compared with t test(t =192.379,t=79.744,P<0.01),the difference was statistically significant,indicating that two groups of treatment scores decreased after treatment.(2)The comparison of the two groups after the treatment of the two groups after treatment was tested by t test(t=-2.496,P<0.05).The difference was statistically significant,indicating that the reduction degree of the treatment group after treatment was better than that of the control group.(5)the contrast of serum concentration of hs-CRP and HcyGroup comparison:(1)the two groups before and after treatment the serum hs-CRP concentration of contrast(t=36.685,t=27.758;P<0.01);(2)compare the serum concentration of Hcy in the two groups before and after treatment(t=47.522,t=26.715;P<0.01)the difference was statistically significant,confirmed after the treatment in the two groups of serum hs-CRP,Hcy the concentration were lower than before.Group comparison:(1)the two groups after treatment compared with the serum concentration of hs-CRP(t=-8.176,P<0.01);(2)compare the serum concentration of Hcy in the two groups after treatment(t=-6.145,P<0.01)the difference was statistically significant,confirmed after treatment,serum hs-CRP and serum Hcy concentration decreased than the control group.Conclusion:(1)The treatment of phlegm and dredging collaterals in acute stage of cerebral infarction(wind phlegm stasis syndrome)has certain clinicalcurative effect.It can regulate abnormal changes of serum hs-CRP and Hcy in patients after onset,reduce neurological impairment,improve daily life ability and improve clinical symptoms.(2)Two groups of treatments improved the levels of serum hs-CRP,Hcy,NIHSS,ADL,DCI and TCMSI in the acute stage of cerebral infarction(wind,phlegm and blood stasis syndrome),but the improvement degree of the treatment group was significantly better than that of the control group,the difference was statistically significant.(3)No obvious side effects were found in the research process.It is safe and effective.It is worthy of clinical promotion.It can improve the scientific basis for treating acute cerebral infarction(wind,phlegm and blood stasis syndrome)by eliminating phlegm and dredging collaterals. |
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