Clinical Study About The Therapeutic Effect Of Acne Syndrome Of Dampness-heat Of Spleen And Stomach By Qingre Lishi Xiaocuo Fang

Objective:Through theoretical research,combined with the literature to explore the knowledge of acne in Chinese medicine;through clinical studies,observe the clinical efficacy and safety of Qingre Lishi Xiaotan Decoction in the treatment of patients with acne spleen and stomach dampness and heat,the main observation index is skin change(skin lesion type,skin Lesion,lesion distribution,number of total lesions,TCM syndrome scores,sex hormones(E2,FSH,LH,testosterone,progesterone)P)),superoxide dismutase(SOD),sex hormone binding globulin(SHBG),etc.,provide a theoretical basis and an effective method for clinical treatment of this disease in traditional Chinese medicine.Methods:Sixty patients of clinical compliance with acne western medicine diagnostic criteria and TCM syndrome belonging to spleen stomach dampness heat syndrome were randomly divided into treatment group and control group according to 1:1 ratio,30 cases in each group.The treatment group qingrelishi Xiaocuo prescription(Yin Chen,gardenia,salvia,Plantago,tuckahoe,Oldenlandia,coix seed etc.)Decoction,1 dose daily;the control group for oral Pudilanxiaoyan tablets,3 times a day,4 tablets at a time.After treatment,patients were evaluated for the change of skin(skin lesions,lesions,lesions distribution,the total number of lesions),TCM syndrome integral,sex hormones(E2,FSH,LH,T,P),changes of SOD,SHBG and other indicators,and record adverse reactions occurred during the treatment period,clinical curative effect and evaluation safety.Results:There was no significant difference in baseline data between the two groups before treatment,such as age and disease duration.The data of the two groups were comparable(P>0.05).Research results suggest:①Improvement of symptoms and signs:The TCM syndrome scores of the treatment group improved significantly after treatment,the total effective rate was 90.00%,and the total effective rate was 63.33%in the control group.The treatment group had better symptoms and signs than the control group.(P<0.05).②Sex hormone levels:T levels decreased after treatment(P<0.05),E2 levels increased(P<0.05)before treatment,but compared between groups,T levels after treatment were higher than after treatment.The control group was significantly lower and the difference was statistically significant(P<0.05).After treatment,the E2 level in the treatment group was significantly higher than that in the control group(P<0.05).Both FSH,LH,and P were positive and negative before and after treatment in both groups.No significant changes.③SOD levels:SOD levels increased significantly after treatment in both groups(P<0.05).④SHBG levels:SHBG levels increased significantly after treatment in both groups(P<0.05).⑤Safety index:60 patients in the treatment group and the control group did not have any adverse reactions after taking medicine,and all the indexes were kept in the normal range.Conclusion:According to clinical research,Qingre Lishi Xiaotanfang can improve the clinical symptoms and signs of patients with acne spleen-stomach dampness-heat syndrome.It not only adjusts the pathological state of endocrine and metabolic disorders in acne patients,but also has no toxic or side effects,is effective,safe and effective,and has extensive applications.prospect.