The Effect Of Dezocine Pretreatment On Dexamethasone-induced Perineal Irritation

Objective We aimed to evaluate the effectiveness of dezocine pretreatment on dexamethasone-induced perineal irritation,and investigate the possible mechanism of dexamethasone-induced perineal irritation.Methods This was a prospective,placebo-controlled,randomized and double-blind Study.A total number of 80 patients scheduled for elective surgery under general anesthesia were allocated to dezocine group(Group D,n=40)or placebo group(Group C,n=40)according to block randomization(male: female =1: 1).Patients received dezocine(Group D)or saline(Group C)intravenously according to the allocation,and then dexamethasone was administered intravenously 10 min later.The injection time of dexamethasone was less than 2 seconds in all patients.Another doctor observed and asked immediately if patients felt pain or pruritus after the injection of dexamethasone.The doctor also need to record the duration and severity(based on VAS)of perineal irritation if the patients felt discomfort.Anesthesia induction was continued with administering midazolam 0.05 mg/kg,propofol 1~2 mg/kg,cisatracurium 0.15 mg/kg,sufentanil 0.3~0.5 ug/kg and the patients were intubated.Results(1)There were no significant differences between the two groups in the patients’ age,height,weight,and ASA physical status(P>0.05).(3)The incidence of dexamethasone-induced perineal irritation was 47.5% in the Group C,which was significantly higher than that(15%)of the Group D(P<0.05).(3)No significant differences in the frequency of mild and severe perineal irritation were noted between the two groups;however,the frequency of moderate perineal irritation was significantly reduced in Group D(P<0.05).(4)The duration of perineal irritation was also significantly shorter in Group D 31±12 s than Group C 59+12 s(P<0.05).Conclusions Dexamethasone administered intravenously appears to induce significant perineal irritation(pain or pruritus).This study confirms that pretreatment with dezocine(0.1 mg/kg)can suppress dexamethasone-induced perineal irritation effectively.