Dezocine Pretreatment Reduces The Injection Pain Of Prorofol A Prospective, Randomized, Double-blind, Placebo Controlled Study

Objective In order to investigate the efficacy and safety ofdezocine pretreatment reduces the injection pain of prorofol, we observed thatthe incidence and severity of injection pain caused by propofol and the the testdrug-related adverse reaction after pretreatment with test drug. Methods160patients(ASAⅠ～Ⅱ), aged19～69yr, body mass index18-25kg/m2scheduledfor operations were randomly allocated to4groups(40cases in each group).The control group received3mL of0.9%sodium chloride solution, thelidocaine group received30mg of lidocaine, the fentanyal group received0.1mg of fentanyal, and the dezocine group received10mg of dezocine. Noneof the patients was premedicated before entering the operation room. Inpreanesthesia room, a20-gauge catheter was inserted into superficial radial veinof the patients, the lactated Ringer’s solution was infused at10mL/kg/h.Onarrival in the operating room, patients were monitored with electrocardiogram,non-invasive arterial pressure, and pulse oximeter. Before anesthetic induction,the infusion was stopped and test drug was administered in10seconds. Patientsin group C received3mL normal saline, group L received lidocaine30mg/3mL,group F received fentanyal0.1mg/3mL and group D received10mg/3mL ofdezocine. We asked the patients if they felt any pain during injection of the testdrug and the pain was assessed on Ambesh four-point scale. Two minutes later,the patients were injected0.5mg/kg of propofol at0.5mL/s with TCI pump. The pain during the injection of propofol was evaluated before loss of consciousnesswith Ambesh four-point scale. After assessment, anesthesia inductioncontinued with administering midazolam0.05mg/kg, fentanyl3μg/kg,cisatracurium0.15mg/kg, propofol1mg/kg and the patients were intubated.Anesthesia was maintained with sevoflurane, remifentanil and cisatracurium.Results1. All patients in four groups had no significant difference indemographics (gender, age, body mass index, ASA class), propofol doses ofanesthesia induction and operative time (P>0.05).2. The overall incidence ofpain on pretreatment drug injection were10%(4/40),5.0%(2/40),7.5%(3/40),and12.5%(5/40) in groups C, L, F, and D, respectively, with no significantdifference between groups. The overall incidence of injection pain afterpropofol injection was82.5%(33/40),50.0%(20/40),70.0%(28/40), and32.5%(13/40) in groups C, L, F, and D, respectively, with group L and groupD showing significantly fewer injection pain than group C(P＜0.05); Theoverall incidence of propofol injection pain in group D was significantly fewerthan group F（P <0.05); There were no significant differences in the overallincidence and degree of injection pain between groups F and C（P＞0.05).3.The overall incidence of adverse effects in group D were significantly fewerthan group F. There were no complications, such as pain, edema, wheal, or flare,observed at the injection site within the2hours after propofol injection in anyof the treatment groups. Conclusion The pretreatment of dezocine reveals notonly lower overall incidence and grade of injection pain after propofol injection, but also fewer adverse effects.