Clinical Observation And Summary Of Rheumatoid Arthritis Treated By Cold And Hot Syndrome Differentiation Of Professor Li Jiren

Objective: "Cold and hot syndrome" is the doctor of medicine physician Professor Li Jiren for rheumatoid arthritis treatment of the core concept,not only in the diagnosis of disease according to the cold and hot properties of its classification and qualitative diagnosis,but also in the treatment of drug use of medicinal properties of cold and hot properties of the consummate.Instructor Professor Li Yan inherited and carried forward the master "cold and hot syndrome differentiation" thinking,and thus in the National Natural Science Foundation of key projects and other topics have made a wealth of research results.In this study,according to the master cold and hot ideas as the premise,through the clinical randomized controlled trial,the subject of cold and hot syndrome differentiation,to observe the traditional Chinese medicine cold and hot syndrome differentiation of rheumatoid arthritis clinical efficacy and treatment safety,and the master medication prescription To summarize the experience of Professor Li Jiren’s treatment,and to provide the basis for the development of Professor Li Jiren’s academic thinking.Methods: 36 patients with rheumatoid arthritis were included in the standard group.The patients were divided into two groups according to the principle of randomized control.The patients in the treatment group were treated with the dialectants by 200 ml and twice daily.In the control group,18 patients were treated with leflunomide 10 mg qd + Methotrexate(MTX)10 mg qw,after 12 weeks of treatment,the main items include: RF,ESR,CRP and other laboratory indicators before and after treatment changes,morning stiffness and tenderness index and other symptoms of disease improvement and after treatment Of the adverse reactions.And use data mining technology to study the Chinese medicine treatment group data mining,and further analysis and summarization of doctors and doctors of cold and hot syndrome differentiation.Results: The curative effect of the two groups was statistically significant(P <0.05).There was no significant difference between the two groups in the improvement of joint symptoms and the reduction of RF and ESR(P> 0.05).In the aspect of TCM syndromes improvement and safety,there was significant statistical difference(P<0.05),the treatment group was better than the control group.Through the data mining analysis,the distribution of symptoms to joint pain,joint swelling,cold pain,chills,physical activity adverse;syndrome distribution mainly to wind cold dampness Bi syndrome,cold and heat syndrome,rheumatism heat Bi syndrome;Followed by the Qufeng dehumidification,cold and collaterals and heat Tongluo;drug analysis of four drugs mainly for the temperature,flat,cold;Wuwei mainly bitter,sweet,Xin;by the main by the liver,spleen,stomach Wait.The use of the prescription in the frequency of more than ten times a total of traditional Chinese medicine,of which,Astragalus,Angelica,large blood vine,Millettia are used more than 30 times the frequency of more than 30 pairs of drugs,the combination of the highest frequency of combination "Astragalus-Angelica" "large blood vine-Millettia" "big vine-Astragalus" "Astragalus-Millettia" and other combinations.When the degree of confidence is 1,the association of the drug rules is more than "angelica"-"Astragalus","big blood vine"-> Millettia "" Sophora flavescens "-> green wind rattan" "big vine,angelica-> Astragalus".Conclusion: Professor Li Jiren use " cold and hot syndrome differentiation " thinking,treatment of rheumatoid arthritis patients with significant effect,similar to the efficacy of the control group."cold and hot syndrome differentiation " treatment of rheumatoid arthritis patients in improving TCM syndrome and adverse reactions are better than the control group.The use of data mining found that " cold and hot syndrome differentiation " the treatment of ideas worthy of attention and promote the application,and continue to study.