Central Mechanism Study By FMRI On Acupuncture Treatment Of Refractory Peripheral Facial Paralysis

1 Objective To explore the central mechanism of acupuncture treatment of refractory peripheral facial paralysis by f MRI technology combined with clinical observation;That’s for providing a basis on clinical acupuncture treatment of the disease.2 Method The experiment was divided into 2 groups: Patients with intractable facial paralysis and healthy control group,each with 10 cases.10 cases of patients with refractory peripheral facial paralysis were collected the data of f MRI under acupuncture bilateral Hegu and clinical Sunnybrook score before and after acupuncture treatment respectively.10 healthy volunteers only need to collect f MRI data when entering group.Task-state f MRI data paralysed by using AFNI software processing results intergroups(Monte Carlo correction,p=0.005,ɑ= 0.05)and results ingroup(Monte Carlo correction,p=0.01,ɑ= 0.05).The comparison of the data between the facial paralysis group and the healthy group(two independent samples t-test)and the changes of Sunnybrook score(paired sample t-test comparion)before and after treatment in the facial paralysis group were analyzed by spss22.0 software system.3 Results(1)The Sunnybrook scales were compared before and after treatment,there were statistically significant differences in the two groups.(1)The results of f MRI data(1)The ingroup’s results of task-data by acupuncture Hegu before acupuncture treatment with the refractory peripheral facial paralysis showed that there were many activated areas in brain,in which,increased signal region: posterior central gyrus,thalamus,insula,central lobe,inferior parietal lobule;reduced signal region: posterior cingulate gyrus,superior frontal gyrus,precuneus,cuneus,fusiform gyrus,lingual gyrus.(2)The ingroup’s results of task-data by acupuncture Hegu after acupuncture treatment with the refractory peripheral facial paralysis showed that there were all increased signal region in brain: posterior central gyrus,precentral gyrus,superior temporal gyrus,cerebellar tonsil,tuber,middle frontal gyrus.(3)The ingroup’s results of task-data by acupuncture Hegu about healthy volunteers showed that there were all increased signal region in brain:lenticular nucleus,inferior frontal gyrus and superior temporal gyrus.(4)The intergroups’ results of task-data by acupuncture Hegu between pre-therapeutic refractory peripheral facial paralysis patients and healthy volunteers had no statistically significant active region(using Monto Carlo method of multi-threshold correction,p=0.01,ɑ= 0.05,Cluster Size=20).(5)The intergroups’ results of task-data by acupuncture Hegu between post-therapeutic refractory peripheral facial paralysis patients and healthy volunteers showed there were increased signal region in brain:middle frontal gyrus.(6)The intergroups’ results of task-data by acupuncture Hegu between pre-therapeutic and post-therapeutic refractory peripheral facial paralysis patients showed that there were all increased signal region in brain: precuneus,cerebellar tonsil,uvula,culmen,fusiform gyrus,inferior occipital gyrus,superior frontal gyrus.4 Conclusion(1)Acupuncture treatment can improve the clinical symptoms of refractory peripheral facial paralysis patients.(2)The reorganization of cerebral functional cortex,such as the cerebellum and DMN related brain area,inferior occipital gyrus may be the central mechanism of acupuncture in the treatment of refractory peripheral facial paralysis.