| Objective: the aim of this study was to evaluate the clinical efficacy,its effect on cognitive behavioristics and the difference of infarction volume in patients with acute cerebral infarction of salvianolic acid with neuropsychological scale and neuroimaging techniques,to elucidate the relationship between the degree of neurological deficit,life ability,quality of life and cognitive domains after stroke and cerebral infarction volume,location and to observe the changes of blood stasis syndrome,to obtain a comprehensive understanding of the whole prescription of Chinese medicine preparation on the effect and mechanism of intravenous intervention on disease progression of ischemic stroke in the process.Method: A total of 90 patients with cerebral infarction who were admitted to the First Affiliated Hospital of Anhui University of traditional Chinese medicine(TCM)were enrolled in this study.The patients with acute cerebral infarction from the age of 45 years old and 80 years old were included in the study.All patients were divided into treatment group(48 cases)and control group(42 cases).Patients with acute ischemic stroke after preliminary screening are confirmed treatment with routine western medicine,and the treatment group was treated added in salvianolic acids(intravenous infusion,100 mg,with 5% glucose or 0.9% Sodium Chloride Solution dilution).The period of treatment is 2 weeks,to observe the clinical efficacy of the two groups,the change of the National Institutes of Health Stroke Scale(NIH Stroke Scale,NIHSS),activities of daily living scale(modified Barthel Index MBI),modified Rankin scale(m RS)and stroke specific quality of life scale(SS-QOL),Montreal cognitive assessment scale(Mo CA)and clock drawing test(CDT),digit span scores and the change of infarction volume.Syndrome score and curative effect of traditional Chinese medicine(TCM)are aslo observed.Results:(1)In effect,compared with the control group,the treatment group in improving the Barthel index,NIHSS score of two groups on the time effect is P<0.01,there were significant differences;group effect P<0.05 was statistically significant;interactive effects of P<0.01,the difference was statistically significant.In the modified Rankin score,the two groups of group effect P<0.05,there was statistically significant differences;there was a statistically significant difference between time and group interaction effect P<0.05.In the SS-QOL score,the interaction effect between time and group P<0.01,the difference was statistically significant.(2)In cognitive aspect,the treatment group and the control group in the MoCA score and CDT score of two groups of treatment effect is P>0.05,showed that the two methods had no significant difference on patients with Mo CA score and CDT score;time effect P<0.05,there was significant differences;the interaction effect is P<0.05,showing statistically significant.On digit span,there were significant differences between the two groups in the treatment effect of P<0.05,the time effect and the interaction effect of P<0.01.(3)In the infarction volume,two groups of treatment effect and interaction effect P<0.05,the difference was statistically significant;the time effect of P>0.05,the difference was not statistically significant.(4)There was a linear relationship between infarct volume and Mo CA score,CDT score,MBI score,NIHSS score,m RS and SS-QOL score,but there was no linear relationship with the digit span.(5)In terms of TCM syndrome,the effective rate of treatment group was 88.09%,which was higher than that of control group(65%),and there was statistical difference between the two groups(P<0.05).In the improvement of TCM syndrome score,the treatment group was better than the control group,P<0.05,the difference was statistically significant.Conclusion:(1)On the observation of curative effect,the effect of salvianolic acid on the recovery of body function,the improvement of neurological function and the improvement of quality of life in patients with acute cerebral infarction were significantly better than those in the conventional treatment group.(2)In terms of cognition,the effect of salvianolic acid on improving the overall cognitive function of the patients was significantly better than that of the conventional treatment group.And it has a significant effect on improving visual spatial ability,working memory and short-term memory.(3)The effect of salvianolic acid on the recovery of cerebral infarction volume in patients with acute stroke was significantly improved.(4)The location of cerebral infarction and the size of infarction volume were correlated with the degree of neurological deficit,the ability of daily living,quality of life and cognitive function.(5)Salvianolic acid can improve the TCM syndrome score and curative effect in acute cerebral infarction with blood stasis syndrome. |
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