Study On The Regulation Of Ginseng On Part Of Physiological Index

Objective:In this study,we observed the physiological function and adverse reaction / event frequency before and after eating ginseng.We compared the effects of ginseng on physiological function of adults with different ages and different constitutions in order to determine the appropriate population of ginseng,and to evaluate the safety of ginseng.Methods:A total of 960 cases of young,middle-aged and old aged between 18-80 years old were selected for clinical study.Among them,320 cases of young group,320 cases of middle age group,320 cases of the elderly group,each group of age have eight constitutions,each constitutions have about 40 cases.We investigated the demographic and social factors.The changes of physical examination,blood routine,liver and kidney function,anti-aging,immune regulation and hormone metabolism were observed and compared before and after 12 weeks of eating ginseng.Epidata3.0 were applied for data entry,IBM SPSS20.0 were used for statistical analysis.Normally distributed data was descriptively reported as mean ± standard deviation.An independent t-test was used to compare two continuous variables.Non-normally distributed data was descriptively reported as median(interquartile range).Nonparametric tests were used to compare the differences between groups.Categorical variables were reported by rate or constituent ratio.The chi-squared test was used to compare the difference between categorical variables.Results:1: The differences of body weight,height,waist circumference and hip circumference in different age groups were statistically significant between different groups of age.The differences of body weight,height,waist circumference and hip circumference were statistically significant between different TCM Constitutions.2: The heart rate increased and diastolic blood pressure decreased in all subjects after eating ginseng.The effects of ginseng on body temperature,heart rate,systolic blood pressure and diastolic blood pressure were similar to those of the whole population.There was a significant difference in systolic blood pressure after young group of subjects eating ginseng.There were significant differences in heart rate and diastolic pressure after mid-age group of subjects eating ginseng.There were significant differences in systolic blood pressure、heart rate and diastolic pressure after elderly group of subjects eating ginseng.3: The hb,wbc and neutrophils increased,the number of platelets increased,the function of blood coagulation increased,and the blood glucose level decreased after eating ginseng.We analyzed the effect of ginseng in different age groups.The levels of hb,wbc and platelet increased,the level of total cholesterol and blood glucose decreased in elderly group.The number of hb,wbc and platelet increased and blood glucose level decreased in middle age group.The number of hb and platelet levels increased,blood glucose levels decreased in the youth group.Ginseng has the effect of lowering blood sugar,increasing hemoglobin and platelet for TCM Constitutions.4: There were significant differences in ALT,AST,TBIL,ALP,ALB,GLO,BUN,CR,SOD,GSH-PX between the two groups before and after 12 weeks of eating ginseng.We analyzed the effect of ginseng in different age groups.There were significant differences in ALT,TBIL,ALP,ALB,GLO,BUN,CR,MDA and GSHPX levels before and after eating ginseng in middle-aged group.There were significant differences in the levels of ALT,ALP,ALB,GLO,CR,MDA,SOD and GSH-PX before and after eating ginseng in the elderly group.There was significant difference in ALT,ALP,GLO,CR,MDA and SOD levels before and after eating ginseng in the youth group.After the experiment of TCM Constitution we found that ginseng consumption can affect the levels of ALT,ALP,GLO,MDA,CR in most of TCM Constitutions.5: The changes of immune and metabolic indexes such as TNF,CD4,CD8,TSH,T3,T4,testosterone and ACTH were changed in all subjects after eating ginseng.There were significant differences in TNF,CD4,CD8,TSH,T3,T4,testosterone,estradiol and ACTH levels before and after eating ginseng in the youth group.There were significant differences in IL-2,TNF,TSH,T4 and estradiol before and after eating ginseng in the elderly group.There were significant differences in TNF,T3,T4,testosterone and ACTH before and after eating ginseng in the mid-age group.Ginseng consumption can affect the TNF,T3 and ACTH levels in the majority of TCM Constitutions,but there was no significant effect on IL-2,CD4 and CD8 levels in all TCM Constitution groups.6: The incidence of adverse reaction was 0%,and the incidence of adverse events was about 15.9%.Conclusion:1: The effect of ginseng on body temperature,heart rate,systolic blood pressure and diastolic blood pressure is influenced by age,but not by TCM Constitution.2: The effect of ginseng on hb,platelet and blood sugar level is not influenced by age and TCM Constitution.3: The effect of ginseng on ALP and GLO is not influenced by age and the constitution of Chinese medicine.CR and MDA are only affected by the constitution of Chinese medicine,while ALT,AST,TBIL,ALB,BUN,SOD and GSH-PX are both influenced by age and influenced by TCM Constitution.4: The effect of ginseng on TNF is not influenced by age and TCM Constitution.T4 is only affected by the constitution of Chinese medicine,while IL-2,CD4,CD8,TSH,T3,testosterone,estradiol and ACTH are both affected by both.5: No serious adverse effects were found in the study population after eating ginseng.