The Exploration Of Therapeutic Mechanism For CVA Treated With Sequential Therapy Of Spasmolysis,Phlegm And Strengthening The Body Resistance

Objective:To explore the pathogenesis of cough variant asthma(CVA)as well as the effect and and mechanisms on chronic airway inflammation and airway remodeling due to sequential therapy of spasmolysis,phlegm and strengthening the body resistance.Methods:This research adopts randomized controlled research methods,collecting xiamen city hospital pediatric outpatient service in line with the "wind phlegm heat" type of infantile cough variant asthma in children with 60 cases,aged 2-14 years of age range,can be divided into the experimental group and control group,30 cases in each group.The experimental group gave two weeks of antispasmolysis to the Chinese traditional Chinese medicine,two weeks of the elimination of sputum,and four weeks of treatment in the soup.The control group was given the use of aerosol aerosols,and the prophase cough was obviously combined with the oral treatment of the procariol,and the total treatment was 8 weeks.To observe the treatment of two groups of children,record and carry out statistical treatment.The other two groups of children in venous blood was collected before and after the treatment 2 ml,heparin anticoagulation,-20℃ refrigerator,reagent for sample sent to Shanghai after collecting completely enzyme-linked reagent to detect biological technology co.,LTD.,are using the ELISA method.Preliminary data carte Blanche enzyme-linked Shanghai biological technology co.,LTD.,late organized and statistical data processing by oneself,come to the conclusion that writing papers.Results:(1)two groups of treatment can reduce cough symptoms and TCM syndrome integral,but the experimental group cough symptoms integral effective rate of 86.7%,Chinese medicine syndrome integral effective rate was 83.3%;In the control group,the effective rate of cough symptom was 60%,and the effective rate of TCM syndrome was 56.7%.The two groups of cough syndrome were compared with P = 0.025<0.05,which showed that the two groups were statistically different,but the treatment group was more effective than the control group.The two groups of Chinese traditional Chinese medicine syndrome were compared with P = 0.030<0.05,which showed that the two groups were statistically different,but the treatment group was more effective than the control group.(2)two methods of treatment on serum IL-12,IL-4,TGF-β,TLR4 content,the experimental group after treatment TLR4,TGF-β content in serum was significantly decreased,the TLR4,TGF-β content in serum and the experimental group were significantly lower than the control group after treatment.The levels of il-12 in the serum were significantly higher than those in the control group and the serum,and the amount of IL-4 was significantly lower than the control group,and IL-12 was negatively correlated with IL-4.The data was processed by statistics,and the influence of the experimental group and the control group on the content of IL-12,IL-4,TGF-βand TLR4 in serum were statistically significant.Conclusion:Two groups treat type "wind phlegm heat" infantile cough variant asthma has exact curative effect,experimental group namely,spasmolysis,phlegm,centralizer sequential treatment of cough variant asthma and control group in the budesonide aerosol joint c quattro treatment of cough variant asthma was statistically difference,so the traditional Chinese medicine(TCM)sequential treatment of type "wind phlegm heat" infantile cough variant asthma is better than that of budesonide aerosol joint c quattro treatment of infantile cough variant asthma,with efficacy and safety,has clinical value.