Study On The Prevalence And Influencing Factors Of Cognitive Dysfunction In Patients With Acute Exacerbation Of Chronic Pulmonary Disease

Purpose:This study evaluated the cognitive competence of patients in the acute exacerbation period of chronic lung diseases, learnt the current situation of their cognitive impairment, and discussed the factors resulting in such cognitive impairment, by applying the mini-mental state examination(MMSE) scale and the minimum obstruction clearance altitude(MOCA) scale, for the purpose to provide theoretical basis to improve the cognitive competence of these patients. Methods:This study evaluated the cognitive impairment of patients recognized, from January to December 2015, by the Respiratory Department of the First Hospital of Jilin University as suffering from chronic lung diseases and admitted to the said hospital for corresponding treatment. Epidata was used here to set the database, the software SPSS19.0 for data analysis, means ± standard deviation or medians(inter-quartile range) for statistical description of data, and T-Test or Chi-square Test for comparison among groups. The multi-factor logistic regression was used to analyze factors leading to cognitive impairment of patients suffering from chronic lung diseases. Results:1.The MMSE scale test results showed that 214 patients had cognitive impairment in different degrees, with the prevalence reaching 63.6%(214/338). In which, 150 patients had mild cognitive impairment(45.5%), while 61 had moderate cognitive impairment(18.5%), and 3 had sever cognitive impairment(0.9%). The Mo CA scale results showed 266 patients had MCI, with the prevalence reaching 78.70%(266/338).2.The MMSE scale test results prove that the Odds ratio of cognitive impairment among patients aged(40~49, 50~59, 60~69, and ≥70) was(6.728, 20.220, 17.983 and 37.984), respectively, of that among patients whose age were less than 40; while the Odds ratio of cognitive impairment among patients getting(primary or lower, junior middle school, senior middle school or technical secondary school) was(14.705, 3.750, and 2.540) of that among college or further educated patients.3.The Mo CA scale results proved that the Odds ratio of cognitive impairment among patients aged(40~49, 50~59, 60~69, and ≥70) was(10.198, 33.284, 27.533 and 47.730), respectively, of that among patients whose age were less than 40; while the Odds ratio of cognitive impairment among patients getting(primary or lower, junior middle school, senior middle school or technical secondary school) was(18.783, 8.717, and 2.710) of that among college or further educated patients.Conclusion:1. The MMSE scale test results proved 63.3% of prevalence of cognitive impairment among the patients, and the Mo CA scale tests results proved 78.7% of prevalence of the same impairment among the same patients2. Patients suffering from chronic lung diseases showed significant cognitive impairment; high age and poor degree of education are dangerous factors leading to cognitive impairment of patients suffering from chronic lung diseases.3. No correlation was found temporarily between disease related indexes and cognitive impairment in patients with chronic pulmonary disease.