The Effects Of Huatan Huoxue Jiedu Recipe On The Heart Function And Coagulation Function In Acute Conoary Syndrome Patients With PCI Sun Dan (Cardiology)

Objective: This study aims to study Clinically relevant changes in indicators in these patients which received standard treatment Combine new drug after treatment with PCI.Preliminary discusses the change aspects of the clotting mechanism in ACS patients after PCI,and give a reasonable explanation Combined with the corresponding results.Method: 63 ACS patients were recruited at the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2015 to January 2016.All the patients were randomly divided into treatment group and control group.Both groups were treated according to the latest recommended guidelines;in addition,the treatment group was supplemented with Chinese herbal compound prescription for resolving phlegm and promoting blood circulation,1 month for every course.The baseline information,clinical biochemistry and related index were collected at the time of admission and after 1 month treatment.Adverse cardiovascular events were observed at any time during treatment.Baseline data were collected at the time of admission of patients which included clinical chemistry and related evaluation indicators and recoved these data after one month.Stay the harmful events Incidence during treatment in the two groups.These indicators include function of Kidney and liver,Conventional Blood examination,TEG,BNP and LVEF which come from Echocardiography.Through SPASS software to analyze and process data and come to the corresponding conclusion.Results:1.General baseline data: Two groups of patients were comparable with the general baseline treatment,and there is no statistical difference(P>0.05).2.coagulation aspect of data analysis:(1)there is no significant difference(P>0.05)before treatment,and the two groups are comparable;(2)The PT of the treatment group was significant(P<0.05)longer than the control group and the FBg of Treatment group was significant(P<0.05)lower.There were no significant difference(P>0.05)of APTT and TT between two groups;(3)After 1 months of treatment,the APTT,PT and TT of the two groups were significantly(P<0.05)longer than those before treatment.FBg was significantly lower(P<0.05).3.TEG aspect of data analysis:(1)Two groups of patients were comparable no significant difference before treatment in TEG related indicators(P>0.05);(2)There were more obvious differences in the value of MA between the control group and the treatment group after treatment(P<0.05),other indicators were no statistical difference in the two groups after treatment(P>0.05);(3)The value of R、K and angle A were increased Compared with the data before treatment in the two groups(P<0.05);the value of MA was reduced compared with the data before treatment in the two groups(P<0.05).4.Heart function aspect of data analysis:(1)The ejection fraction measured by echocardiography was no significant difference in the control group and the treatment group before treatment(P>0.05);(2)After treatment,The value of BNP was statistically significant differences between the two groups(P<0.05);(3)Before and after treatment,there were no significant differences between the two groups in the aspect of LVEDD(P>0.05)5.The score of symptoms before and after treatment:(1)Before treatment:there was no statistical significance between the two groups in the score of symptoms(P>0.05);(2)After treatment: the score of symptoms decreased significantly than before treatment(P>0.05)and there was statistical differences with comparion between control group and treatment group.6.Comparison of incidence rate of major adverse events: there was no significant difference in incidence of major adverse events between the two groups during the follow-up period.Conclusion: On the basis of conventional western medicine treatment,the addition of phlegm and blood stasis can significantly improve the blood coagulation function and the recent heart function,and does not increase the incidence of major adverse events,indicating better clinical benefit and safety of Huatan Huoxue Jiedu Recipe for the improvement of the blood coagulation function and the recent cardiac function in patients with acute coronary syndrome after PCI.