Investigation Of The Blood Lipid Levels In Healthy People Aged Over 45 In Zhengzhou Area

ObjectiveTo investigate the blood lipid levels and the incidence of dyslipidemia in healthy people aged over 45 in Zhengzhou area, and analyze the blood lipid levels and dyslipidemia in different age and gender groups. Methods1.911 healthy adults in Zhengzhou area aged over 45 were chosen and divided into three groups according to the age: middle-aged group(45 to 59 years old, group A), pre-elderly group(60 to 74 years old, group B), the elderly group(75 years old, group C).2.All participants general data was collected, including age, gender, smoking, drinking, history, etc., and the body height, weight, body mass index, waist circumference, hip circumference, systolic blood pressure(SBP), diastolic blood pressure(DBP), chest X-ray, electrocardiogram, blood routine, etc.were checked. were Full-automatic biochemistry analysis instruments was adopted to determine lipid four and general biochemical data(fasting plasma glucose, FBG), liver and kidney function). Blood lipid levels and the incidence of dyslipidemia in different groups and gender groups were analyzed and compared.3.Statistical analysis: SPSS17.0 statistical software was used for statistical analysis. Measurement data are presented as mean±standard deviation. Independent samples t-tests was used to compare variables between two groups. ANOVA was used to compare variables among multiple groups,and S-N-K method was taken to compare variables between each two groups.Count data are presented as percentage, comparison between two groups of count data was presented by chi-square test. A P-value smaller than 0.05 was considered significant. Results1 Baseline data comparison:Gender, BMI, systolic pressure, diastolic blood pressure, waist circumference,smoking history, history of drinking among the three groups were not statistically significant, while age was statistically significant(P<0.05).2.Compared with overall blood fats levels in male, TC. LDL and HDL-C levels increased in female, and the difference was statistically significant(P<0.05), while TG level had no significant difference(P>0.05);3. Blood fats levels comparison among the three groups: TC level in group A, B, C is 4.66±1.13mmol/L、4.70±1.00mmol/L、4.91±1.03mmol/L respectively, and had no significant difference(P>0.05)among the three groups; TG level in group A, B, C is 1.49±1.12mmol/L、1.62±1.34mmol/L、1.56±1.20mmol/L respectively; LDL-C level in group A, B, C is 2.62±1.92mmol/L 、 2.70±0.98mmol/L 、 2.86±0.83mmol/L respectively; HDL level in group A, B, C is 1.39±0.36mmol/L、1.38±0.47mmol/L、1.27±0.34mmol/L respectively, and TC level、TG level、LDL-C level、HDL level had no significant difference(P>0.05)among the three groups;4.Compared with male in the three groups, TC and LDL-C level increased in female, LDL-C level reduced in female, and the differences were both statistically significant(P<0.05); Compared with lipid levels in women of group A, TC and LDL-C levels were significantly higher in women of group B and group C(P<0.05);Compared with lipid levels in women of group B, TC and LDL-C levels were significantly higher in women of group C(P< 0.05); Compared with lipid levels in men of group A, TC and LDL-C levels were significantly higher in men of group B and group C(P<0.05);Compared with lipid levels in men of group B, TC and LDL-C levels were significantly higher in men of group C(P< 0.05);5. The rate of dyslipidemia comparison among the three groups: compared with male, the incidence of hypercholesterolemia、high LDL-C increased in female among the three groups, and the incidence of low HDL-C reduced among the three groups,and the differences were statistically significant(P<0.05). Compared with women in group B and A, the incidence of high TC and LDL-C increased in women in group C(P<0.05);compared with women in group A, the incidence of high TC and LDL-C increased in women in group B(P<0.05).Compared with men in group B and A, the incidence of high LDL-C increased in men in group C(P<0.05);compared with men in group A, the incidence of high LDL-C increased in men in group B(P<0.05). Conclusion1. TC and LDL-C levels 、the incidence of high TC and LDL-C increased with age in middle-aged and old women, which were higher than men in the age-matched groups respectively.2. TC and LDL-C levels 、the incidence of high LDL-C increased with age in middle-aged and old men. The incidence of low HDL-C of men were higher than women in the age-matched groups.