The Clinical Research Of Multiple Myeloma Cytogenetic Abnormalities

Objective:This study analyzes the clinical features in multiple myeloma with common cytogenetics and the relationship between cytogenetics and prognosis of patients,aimed at screening prognostic factors affecting MM patients, survival.Methods:57 diagnosed patients in the second hospital of Shanxi medical university with MM,from January 2010 to January 2015,all patients received chemotherapy based in bortezomib,using FISH to detect cytogenetics,the probes including 17p13.1(P53)、1q21、13q14(RB1)、13q14.3(D13S319)、14q32(IGH).Collect the clinical data of patients,followed up the patients,the median follow-up time was 20 months,statistic the progression free survival and overall survival,analyze the relationship between cytogenetics and patients, survival time.Results:1.All patients investigated by FISH,cytogenetic aberrations were found in 31(54%)patients, 17 p deletions,D13S319 deletions,RB1 deletions,chromosome 1q amplification were observed in 5%、28%、28%、43.9%、33.3% cases;2.50 patients detected by conventional karyotypic,cytogenetic aberrations were found in 11(24.4%) patients;3.The patients with 1q21 amplification have higher ESR、 Cr、calcium concentration,lower haemoglobin concentration and platelet count,the patients with p53 deletion are more likely to have extramedullary infiltration,the patients with D13S319 deletion have higher plasmacyte in bone marrow;4.The patients with 1q21 amplification 、 p53 deletion 、D13S319 deletion 、 calcium concentration greater than 3mmol/L have short PFS,with1q21 amplification、p53 deletion、calcium concentration greater than 3mmol/L have short OS;5.The patents with 1q21 amplification and p53 deletion have poor prognosis.Conclusions:1.The MM cytogenetics detection rate is significantly improved by FISH than conventional karyotypic; 2.Most of the cytogenetic abnormalities in MM patients are complex karyotype; 3.The patents with 1q21 amplification、 p53 deletion 、 D13S319deletion、calcium concentration greater than 3mmol/L have poor prognosis.4.The 1q21 amplification and p53 deletion are independent prognosis factors of PFS,the p53 deletion is independent prognosis factor of OS.