The Correlation Among The Expression Levels Of Serum PGE2,degree Of Pain And Postherpetic Neuralgiain In Patients With Herpes Zoster

Objective: Study on expression level of serum PGE2, different stages of herpes zoster pain, to find the relations of PGE2,pain degree and postherpetic neuralgia in different stages of herpes zoster.Method: 1.40 Patients with HZ and 40 healthy people from the Medical Center were collected to compared with enzyme-linked immunosorbent assay(ELISA) before treatment, after treatment and control groups respectively serum PGE2 expression level for testing from November of 2014 to November of 2015. 2.Using a visual analog score(VAS)for evaluating pain scores between before treatment patients and after treatment patients.3.Then analysis the correlation among the expression level of PGE2 in HZ,pain degree,pain of postherpetic neuralgia(PHN), and discuss risk factors for PHN.Results: 1. the PGE2 levels before treatment for patients with HZ(98.68 30.87) ng/ml, significantly higher than the treatment(76.88 26.67) ng/ml and the control group(50.26 24.22) ng/ml. 2. in HZ, PGE2 expression level before treatment of PHN Group(129.52 22.30) ng/ml,after treatment(107.56 15.09) ng/ml; non-PHN PGE2 expression level before treatment(86.98 25.19) ng/ml after treatment(65.24 19.97) ng/ml;PHN group and non-PHN before treatment, after treatment, there were significant differences in expression level of PGE2(P<0.05), there were significant. 3. in HZ, VAS scores before treatment for PHN Group(8.18 ± 0.87),after treatment(4.9 ± 1.13); for non-PHN VAS scores before treatment(6.17 ± 0.75),after treatment(1.79 ±0.81); non-PHN group and PHN group before treatment, after treatment of the VAS scores were significantly different(P<0.05), there were significant. 4. HZ before treatment in patients with serum expression level of PGE2(76.88 26.67) ng/ml, and the VAS score(6.72 ± 1.20) is positively correlated correlation coefficient r = 0.457, P< 0.05; patients after treatment in patients with serum expression level of PGE2(76.88 26.67) ng/ml, and the VAS score(2.65 ± 1.67) are positively correlated correlation coefficient r = 0.598, P< 0.05. 5.Compared with non-PHN group and PHN group, age, with or without associated diseases, initial medical care differences were significant(P<0.05), there were significant.Conclusion: 1. The expression level of PGE2 of patients with HZ before and after treatment were significantly higher in the control group, suggesting that PGE2 involved in the pathogenesis of HZ. 2.Patients of HZ with high expression levels of PGE2 may larger probability occur PHN. Prompt PGE2 expression level to a certain extent, can be to predict the occurrence of PHN. 3.Patients of HZ with high VAS scores may larger probability of PHN, Tip pain in PHN can occur up to a certain extent to predict the occurrence of PHN. 4. PGE2 expression levels were positively associated with the degree of pain in different periods of HZ patients. Can prompt PGE2 expression level in a certain extent, can be used as a judge index of degree of pain. 5. This study further confirms that the age, concomitant diseases, initial medical care are risk factors for PHN.