Investigation Of Antihypertensive Drug Utilization In Community Residents Of Yancheng City

Objectives:We want to study the incidence of hypertension, to analyze the utilization of antihypertensive drugs, to investigate the influencing factors and medication compliance of hypertension, and to observe the hypotensive effect of antihypertensive drugs in community residents through the survey. These will provide a reference basis for the rational use of drugs for hypertension patients in community residents of Yancheng City.Methods:From 2013.12～2014.2,397 hypertensive patients, randomly selected from 8 living areas of community, were surveyed by questionnaires to understand the status of the hypertension patients blood pressure level distribution, to evaluate the cardiovascular risk, and to study the distribution of blood pressure as well as medication situation, such as drug varieties, defined Daily dose (DDDs), defined daily dose cost(DDDc), drug utilization index (DUI). Medication compliance was measured by Morisky method. We also analyzed the influential factors. Combined with blood pressure control target, the hypotensive effect and the influential factors were assessed. SPSS 20.0 software was used to analysis. We carried single factor analysis by using χ2test. The meaningful influence factors of compliance and antihypertensive effect are analysised by binary logistic regression and logistic regression analysis.Results:This research shows that:1. Most of hypertensive patients in community were at middle and high risks, with man 36.6% and 27.8%, woman 29.7% and 30.7% respectively. The main causes of the disease included gene, smoking, obesity and diet habits.2. Hypertensive patients at low risk taken ARB or CCB alone, and patients at middle, high and extremely high risks all taken ARB combined with β receptors antagonists. The top 5 drugs in DDDs (from high to low) were:Compound Hypotensive Tablets、Extended Release Nifedipine Tablets、 Telmisartan Tablets、Amlodipine Besylate Tablets and Zhenju Jiangya Tablet. And the last 5 drugs in DDDc (from low to high) were Compound Hypotensive Tablets、Zhenju Jiangya Tablet、Losartan Potassium Tablets、Extended Release Nifedipine Tablets and Losartan Potassium Tablets (Merck). Among these drugs,61.5% were basic drugs and the DUI was about 1.0.3. The medication compliance of hypertensive patients in community was low, with low compliance of 31.5% and middle compliance of 27.0%. Main influencing factors are as followed in proper order:drug types, antihypertensive effect, drug use frequency, cultural degree, family history, dangerous degree, drinking, age and medication time.4. The blood pressure control rate of hypertensive patients in community was low, which was about 26.4%. Main influencing factors are as followed in proper order:number of types of drugs, medication, dangerous degree, exercising, eating fruit, eating vegetables, salt and medication time.Conclusion:The anti-hypertensive drugs were rationally used in District of Yancheng city, while the control rate of blood pressure was not high as the low drug compliance and the deficiency of effective non-medication treatments. We suggest the community health service station should improve the diagnosis and treatment level of medical staff, to Publicize the knowledge of hypertension, to establish and improve archives in hypertensive patients, and to enhance basic drug use frequency.